1. Basic Product Information

• Full Name: Rivaroxaban
• Aliases: BAY 59-7939, 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
• CAS No.: 366789-02-8
• EINECS No.: 685-132-2
• Molecular Formula: C19H18ClN3O5S
• Molecular Weight: 435.88
• Chemical Classification: Chiral oral anticoagulant API, selective Factor Xa inhibitor, cardiovascular pharmaceutical raw material
• Core Product Features
  Single S chiral configuration, high HPLC purity complying with USP/EP pharmacopoeia standards; direct oral factor Xa inhibitor with high bioavailability, stable crystal form, low related impurities. Widely used in finished anticoagulant tablet production, cardiovascular drug R&D and pharmacological laboratory research, strict heavy metal and residual solvent control for pharmaceutical grade requirements.

2. Detailed Physical & Chemical Properties

2.1 Physical Properties

1. Appearance: White to off-white crystalline powder, uniform fine particles, no caking, no foreign impurities
2. Odor: Odorless
3. Solubility: Practically insoluble in water, ethanol; soluble in DMSO, slightly soluble in DMF; insoluble in aliphatic hydrocarbons
4. Specific Optical Rotation [α]D20: -34 ~ -44° (c=0.3, DMSO)
5. Melting Point: 228–232℃ (decompose slowly upon melting)
6. Boiling Point: 732.6±60.0℃ (predicted, thermal decomposition occurs before boiling)
7. Density (Predicted): 1.46 g/cm3
8. Hygroscopicity: Slightly hygroscopic, must be stored under light-proof sealed low-temperature environment

2.2 Chemical Properties

1. Chiral Stability: Single S stereoisomer, no obvious racemization under sealed storage at 2–8℃; long-term high temperature will damage chiral configuration
2. Pharmacological Mechanism: Selective reversible inhibition of coagulation factor Xa, blocks thrombin generation and suppresses blood clot formation
3. Acid & Alkali Stability: Stable under neutral and weak acidic conditions; easy hydrolysis under strong alkaline heating; compatible with neutral pharmaceutical excipients
4. Photostability: Sensitive to strong ultraviolet light, easy to oxidize and discolor under direct sunlight
5. Thermal Stability: Stable below 200℃; temperature over 230℃ triggers molecular decomposition
6. Compatibility: Incompatible with strong oxidants, concentrated strong alkali and reducing agents

3. Comprehensive Product Applications

3.1 Pharmaceutical API for Anticoagulant Drugs (Core Application)

1. Prevent deep vein thrombosis (DVT) and pulmonary embolism (PE) after hip/knee orthopedic surgery;
2. Reduce stroke and systemic embolism risk for non-valvular atrial fibrillation patients;
3. Treat recurrent venous thromboembolism and prevent cardiovascular events after acute coronary syndrome.
   High oral bioavailability (80–100%), convenient once-daily administration instead of warfarin regular blood monitoring.

3.2 Pharmaceutical Synthesis Intermediate

3.3 Biomedical Research Reagent

4. Full Parameter Specification Table