Bicalutamide
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
430.37
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Bicalutamide
CAS Number: 90357-06-5
Alias: ICI-176334, Casodex
Chemical Name: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
Molecular Formula: C18H14F4N2O4S
Molecular Weight: 430.37
IUPAC Name: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide
Structural Information
- Structure Type: Non-steroidal anti-androgen, fluorinated aromatic amide
- Structural Features: Contains cyano, trifluoromethyl, fluorophenyl sulfonyl and hydroxyl groups; racemic mixture, R-enantiomer carries all anti-androgen activity, S-enantiomer almost inactive
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: 191–193 °C
- Density: 1.52 g/cm3 (predicted)
- Boiling Point: 650.3 °C (predicted)
- Solubility: Practically insoluble in water; soluble in acetone, THF, DMSO; sparingly soluble in methanol; slightly soluble in ethanol, chloroform
- Stability: Stable under normal room temperature; light-sensitive; incompatible with strong oxidants and strong alkalis
Synthesis & Applications
Production Method
Multi-step chemical synthesis: Epoxidation of methyl methacrylate, coupling with 4-fluorothiophenol, sulfoxidation, hydrolysis, acyl chloride formation, final condensation with 3-trifluoromethyl-4-cyanoaniline, recrystallization purification
Main Applications
- Pharmaceutical API: Oral anti-androgen drug for prostate cancer treatment; blocks androgen receptor to inhibit tumor growth
- Clinical Use: Combined with LHRH analogs for advanced metastatic prostate cancer; monotherapy for local advanced non-metastatic prostate cancer
- Biochemical Research Tool: Androgen receptor antagonist for cell & molecular biology experiments
Safety & Storage Instructions
- Hazard Classification: Irritant (Xi); irritates skin, eyes and respiratory tract; avoid oral intake by non-patients
- Personal Protection: Dust mask, chemical goggles, nitrile gloves; avoid dust inhalation and direct skin contact
- Storage Condition: Sealed, cool, dark, dry warehouse; 2–8°C recommended; light-proof, moisture-proof, separate from oxidants
- Transportation: Class 9 miscellaneous dangerous goods (UN3077), packaging grade III; prevent sunlight, dampness and breakage
Quality Specifications
- Purity: ≥99.0% (HPLC)
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single Unknown Impurity: ≤0.1%
- Total Impurities: ≤0.5%
- Melting Range: 191–193 °C
Information Summary Table
| Item | Specification |
| CAS Number | 90357-06-5 |
| Product Name | Bicalutamide |
| Synonym | Casodex, ICI-176334 |
| Molecular Formula | C18H14F4N2O4S |
| Molecular Weight | 430.37 |
| Appearance | White to off-white crystalline powder |
| Melting Point | 191–193 °C |
| Solubility | Soluble in DMSO/acetone, insoluble in water |
| Purity | ≥99.0% |
| Storage Condition | Sealed, cool dark place, 2–8°C, light-proof |
| Hazard Property | Skin/eye/respiratory irritant, Class 9 hazardous goods |
| Main Usage | Anti-prostate cancer API, AR antagonist research reagent |
