Atorvastatin calcium
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
1155.34 g/mol
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Atorvastatin calcium
CAS Number: 134523-03-8
Alias: Atorvastatin calcium trihydrate
Molecular Formula: C66H68CaF2N4O10
Molecular Weight: 1155.34 g/mol
IUPAC Name: Calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate
Structural Information
- Structure Type: Synthetic statin compound, chiral organic calcium salt
- Structural Features: Contains pyrrole ring, fluorophenyl group and multiple chiral carbon centers. It exists as calcium salt with stable molecular structure, presenting excellent lipophilicity and specific enzyme inhibitory activity.
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: 176–178 °C
- Solubility: Slightly soluble in water; soluble in methanol, ethanol and dimethyl sulfoxide; practically insoluble in non-polar organic solvents
- Stability: Stable under sealed, cool and dark conditions. Decomposes under high temperature, intense light and strong oxidizing environment. Sensitive to strong acid and strong alkali.
Synthesis & Applications
Synthesis Method
Produced via multi-step asymmetric synthesis, cyclization and coupling reactions using fluorinated aromatic compounds and chiral intermediates. The crude product is purified, then reacted with calcium salt for salification, followed by recrystallization and drying to obtain the finished product.
Main Applications
- Pharmaceutical Field: Main active ingredient of lipid-lowering drugs. Selectively inhibits HMG-CoA reductase, effectively reducing total cholesterol, triglycerides and low-density lipoprotein in blood.
- Medical Treatment: Widely used for the treatment of hyperlipidemia, coronary heart disease and atherosclerosis.
- Biochemical Research: Standard reference substance and experimental reagent for lipid metabolism and cardiovascular drug research.
Safety & Storage Instructions
- Hazard Classification: Pharmaceutical raw material, mild irritant. Long-term improper use may cause adverse reactions to liver and muscle.
- Personal Protection: Wear dust mask, safety goggles and chemical resistant gloves. Avoid inhalation of dust and direct contact with skin and eyes.
- Storage Condition: Keep containers tightly sealed. Store in cool, dry, dark and well-ventilated area. Keep away from heat sources, oxidants and corrosive substances.
- Transportation: Classified as general pharmaceutical chemicals. Prevent package damage, moisture and prolonged exposure to sunlight during transit.
Quality & Spectral Data
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Total Related Substances: ≤1.0%
- IR Spectrum: Characteristic absorption peaks conform to standard reference spectrum
Information Summary Table
| Item | Specification |
| CAS Number | 134523-03-8 |
| Product Name | Atorvastatin calcium |
| Synonym | Atorvastatin calcium trihydrate |
| Molecular Formula | C66H68CaF2N4O10 |
| Molecular Weight | 1155.34 g/mol |
| Appearance | White crystalline powder |
| Melting Point | 176–178 °C |
| Solubility | Slightly soluble in water; soluble in methanol and ethanol |
| Purity | ≥99.0% (HPLC) |
| Storage Condition | Sealed, cool dry dark place, away from oxidants |
| Hazard Property | Mild irritant, pharmaceutical active ingredient |
| Main Usage | Lipid-lowering pharmaceutical raw material, biochemical research reagent |
