Sitagliptin phosphate monohydrate
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
523.32
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White or almost white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
IUPAC Name: Sitagliptin phosphate monohydrate
CAS Number: 654671-77-9
Common Name: Sitagliptin phosphate monohydrate
Alias: MK-0431, Sitagliptin phosphate hydrate
Molecular Formula: C16H20F6N5O6P
Molecular Weight: 523.32 g/mol
Structural Information
- Structure Type: Fluorinated heterocyclic compound, classified as dipeptidyl peptidase 4 (DPP-4) inhibitor.
- Structural Features: The molecular structure consists of trifluorophenyl moiety and triazolopyrazine core skeleton. This compound is presented in the form of phosphate monohydrate salt, with stable crystal structure and definite hydration state.
Physical & Chemical Properties
- Appearance: White or almost white fine crystalline powder
- Odor: Odorless
- Melting Point: Not determined
- Solubility: Freely soluble in water and DMSO; slightly soluble in ethanol; practically insoluble in non-polar organic solvents such as hexane and ether
- pH Value (Aqueous Solution): Weakly acidic
- Stability: Chemically stable under normal ambient temperature and humidity. Avoid long-term exposure to strong light and high temperature environment.
Synthesis & Applications
Synthesis Method
The product is prepared through multi-step asymmetric organic synthesis. After completing the construction of the parent molecular structure, it undergoes acid-base reaction to form phosphate salt, then refined by recrystallization process to obtain high-purity monohydrate finished product.
Main Applications
- Pharmaceutical API: Main raw material for hypoglycemic drugs, widely used in the preparation of finished medicines.
- Pharmacological function: A highly selective DPP-4 inhibitor. It can prolong the action time of endogenous incretin, effectively regulate blood glucose level, and is clinically applied for the treatment of type 2 diabetes mellitus.
- Research use: Used for pharmacological experiments, drug formulation research and related academic research in pharmaceutical laboratories.
Safety & Storage Instructions
- Hazard Classification: Low toxic compound, non-corrosive, non-irritant under normal use.
- Personal Protection: Wear conventional lab protective gloves and dust mask during handling. Avoid direct contact with eyes and mucous membranes.
- Storage Condition: Keep tightly sealed. Store in dry, dark and ventilated place at -20 °C. Separate from oxidants and strong acids.
- Transportation: Belongs to general pharmaceutical chemicals. Transport in sealed packaging, no special dangerous goods transportation regulations required.
Quality & Spectral Data
- Purity (HPLC): ≥99.0%
- Loss on Drying: Complies with monohydrate standard requirements
- 1H NMR Spectrum: Consistent with standard reference spectrum
- IR Spectrum: Characteristic absorption peaks match the standard structure
Information Summary Table
| Item | Specification |
| CAS Number | 654671-77-9 |
| Product Name | Sitagliptin phosphate monohydrate |
| Synonym | MK-0431, Sitagliptin phosphate hydrate |
| Molecular Formula | C16H20F6N5O6P |
| Molecular Weight | 523.32 g/mol |
| Appearance | White or almost white fine crystalline powder, odorless |
| Solubility | Soluble in water, DMSO; Slightly soluble in ethanol; Insoluble in alkanes and ethers |
| Purity | ≥99.0% (HPLC) |
| Storage Condition | Sealed, dry, dark, stored at -20 °C |
| Hazard Property | Low toxicity, general chemical |
| Main Usage | Anti-diabetic API, DPP-4 inhibitor, pharmaceutical research reagent |
