Tigecycline
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
585.65
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Orange crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
Tigecycline is a broad-spectrum glycylcycline antibiotic, a semi-synthetic derivative of minocycline, designed to combat multidrug-resistant (MDR) bacterial infections. It exhibits potent activity against both Gram-positive and Gram-negative bacteria, including MRSA, VRE, and carbapenem-resistant Enterobacteriaceae. For research and pharmaceutical manufacturing use only; not for direct human administration.
Product Features
- High Purity: ≥98.0% (HPLC), meets EP/USP reference standard grade.
- Broad-Spectrum Activity: Active against Gram-positive, Gram-negative, and anaerobic bacteria, including MDR strains.
- Novel Mechanism: Binds to the 30S ribosomal subunit, inhibiting protein synthesis; evades common tetracycline resistance mechanisms (ribosomal protection, efflux pumps).
- Chemical Stability: Stable under recommended storage; sensitive to light and moisture.
- Quality Assurance: COA, MSDS, and GMP documentation available upon request.
Physical & Chemical Properties
Physical Properties
- Appearance: Orange to orange-red crystalline powder.
- Molecular Formula: C??H??N?O?
- Molecular Weight: 585.65
- Melting Point: 164–166 °C
- Boiling Point: ~890.9 °C (predicted)
- Density: 1.455 g/cm3 (20 °C)
- Solubility: Soluble in DMSO (≥25 mg/mL), slightly soluble in water; insoluble in non-polar solvents.
- Storage Condition: -20 °C, sealed, dark, inert atmosphere; 3-year shelf life (powder).
Chemical Properties
- Stability: Stable in solid form at -20 °C; solutions in DMSO stable for 1 month at -20 °C.
- Reactivity: Contains multiple hydroxyl, amide, and amine groups; undergoes oxidation, hydrolysis under strong acid/base.
- pKa: ~4.5 (predicted)
- Incompatibility: Avoid strong oxidants, strong acids, and direct sunlight.
Applications
- Pharmaceutical API: Active pharmaceutical ingredient for Tigecycline for Injection (brand name Tygacil), used in treating complicated skin/soft tissue infections, intra-abdominal infections, and community-acquired pneumonia.
- Antibiotic Research: Reference standard for antimicrobial susceptibility testing and MDR bacteria research.
- Oncology Research: Investigational agent for targeting cancer stem cells (e.g., AML) via inhibiting mitochondrial protein translation.
Storage & Transportation
Storage
- Temperature: -20 °C (long-term); 2–8 °C (short-term, ≤1 month).
- Environment: Sealed, dark, dry, inert gas (nitrogen) protection.
- Handling: Aliquot after reconstitution to avoid repeated freeze-thaw cycles.
Transportation
- Condition: Dry ice shipment (maintain ≤-20 °C); avoid light and moisture.
- Packaging: Sealed aluminum foil bag or glass vial with desiccant.
Regulatory Information
- CAS Number: 220620-09-7
- EINECS: Not listed (pharmaceutical compound)
- HS Code: 2941909090 (antibiotic API)
- UN Number: Not classified (non-hazardous for transport)
- Quality Standard: USP, EP, Chinese Pharmacopoeia (ChP)
Full Parameter Table
| Item | Specification |
| Product Name | Tigecycline |
| CAS NO. | 220620-09-7 |
| Synonyms | 9-tert-Butylglycylamidominocycline, GAR-936 |
| Molecular Formula | C??H??N?O? |
| Molecular Weight | 585.65 |
| Appearance | Orange crystalline powder |
| Purity | ≥98.0% (HPLC) |
| Water Content | ≤0.5% |
| Melting Point | 164–166 °C |
| Solubility | DMSO: ≥25 mg/mL; Water: Slightly soluble |
| Storage | -20 °C, sealed, dark |
| Shelf Life | 3 years (powder, -20 °C) |
| Packing | 1g/5g/10g aluminum foil bag or glass vial |
| Grade | Pharmaceutical API / Research Grade |
