(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
solid
|
| Molecular Weight |
172.61
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Light yellow to brownish solid
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile is a high-purity chiral heterocyclic compound and key pharmaceutical intermediate. It appears as light yellow to brownish solid, featuring excellent chiral selectivity and stable chemical properties. Produced via asymmetric synthesis, purification and recrystallization, this product meets strict standards for pharmaceutical synthesis. For legitimate pharmaceutical production and scientific research only.
Product Features
- High Purity & Chiral Purity: Total purity ≥99.0% (HPLC), chiral purity ≥99.0%, stable isomer configuration.
- High Reaction Activity: Containing chloroacetyl and cyano active groups, easy to carry out nucleophilic substitution and coupling reactions.
- Good Storage Stability: Maintains stable properties under low temperature and sealed environment.
- Strict Quality Control: Full batch inspection; COA and MSDS are available upon request.
Physical & Chemical Properties
Physical Properties
- Appearance: Light yellow to brownish solid
- Molecular Formula: C7H9ClN2O
- Molecular Weight: 172.61
- Melting Point: 52 – 53 °C
- Density: 1.27 g/cm3
- Boiling Point: 363.1 °C
- Flash Point: 173.4 °C
- Solubility: Slightly soluble in methanol, DMSO and chloroform; insoluble in water
- Hygroscopicity: Slightly hygroscopic
Chemical Properties
- Chemical Stability: Relatively stable under inert gas protection and low temperature; easy to hydrolyze when exposed to high temperature, moisture and strong alkalis.
- Chemical Reactivity: Chloroacetyl group is prone to nucleophilic substitution reaction; cyano group can participate in cyclization and hydrolysis reactions.
- Acid-Base Character: Neutral.
- Incompatibility: Keep away from strong bases, strong oxidants and high humidity environment.
Applications
- Pharmaceutical Intermediate: Core raw material for the synthesis of vildagliptin, alogliptin and other DPP-4 inhibitor drugs, which are widely used for the treatment of type 2 diabetes.
- Chiral Synthesis Research: Applied to the research and development of new chiral drugs and asymmetric organic synthesis.
- Fine Chemicals: Used for the preparation of various pyrrolidine derivative compounds.
Storage & Transportation Instructions
Storage Conditions
Store at 2 – 8 °C, keep containers tightly sealed, dry and away from light. Nitrogen protection is recommended for long-term storage. Reseal containers immediately after opening.
Transportation Requirements
Classified as non-hazardous goods. Adopt sealed and light-proof packaging. Avoid collision, extrusion, high temperature and rain during transit. Do not transport together with strong alkalis, oxidants and corrosive substances.
Operation Notes
Wear dust mask, chemical-resistant gloves and safety goggles. Operate in a well-ventilated fume hood. Avoid inhalation of dust and direct contact with skin and eyes. Rinse thoroughly with plenty of clean water in case of contact. No eating, drinking or smoking in the working area.
Regulatory Information
EINECS Number: 807-388-8
HS Code: 2933990990
Complies with pharmaceutical intermediate standards. Export products follow relevant international regulations. All transactions are limited to qualified pharmaceutical factories and research institutions.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile |
| CAS NO. | 207557-35-5 |
| IUPAC Name | (2S)-1-(Chloroacetyl)pyrrolidine-2-carbonitrile |
| Synonyms | (2S)-N-Chloroacetyl-2-cyanopyrrolidine, Vildagliptin Intermediate |
| Molecular Formula | C7H9ClN2O |
| Molecular Weight | 172.61 |
| EINECS Number | 807-388-8 |
| UN Number | Non-hazardous goods |
| Hazard Class | Irritant |
| Appearance | Light yellow to brownish solid |
| Purity | ≥99.0% (HPLC) |
| Chiral Purity | ≥99.0% |
| Melting Point | 52 – 53 °C |
| Density | 1.27 g/cm3 |
| Solubility | Slightly soluble in methanol, DMSO, chloroform; insoluble in water |
| HS Code | 2933990990 |
| Storage Temperature | 2 – 8 °C, sealed, dry & light-proof environment |
| Packing Specification | 1kg/5kg aluminum foil bag, 25kg fiber drum with inner plastic bag |
| Grade Standard | Pharmaceutical Intermediate Grade / Research Grade |
| Application Scope | Intermediate for vildagliptin and alogliptin, chiral synthesis reagent |
| Validity Period | 24 Months under specified storage conditions |
