Product Overview

Product Features

• High Stability: Stabilized with poly-L-lysine/CMC, resistant to nuclease degradation.
• Potent Immune Stimulation: Strong interferon inducer; activates NK cells, T cells, and cytokines.
• Biocompatible: Low toxicity; well-tolerated in preclinical and clinical settings.
• Sterile & Endotoxin-Free: ≥98% purity (HPLC); ≤0.1 EU/μg endotoxin.
• GMP-Grade: Compliant with pharmaceutical research standards; COA/MSDS available.

Physical & Chemical Properties

Physical Properties

1. Appearance: White to off-white lyophilized powder
2. Odor: Odorless
3. Molecular Formula: (C10H13N4O8P)x·(C9H14N3O8P)x·(C6H9O5)y·(C6H12N2O)z
4. Molecular Weight: ~500,000–1,000,000 Da (polymeric)
5. Solubility: Freely soluble in water; insoluble in organic solvents
6. pH: 6.5–7.5 (1% aqueous solution)
7. Storage Form: Lyophilized (sterile)

Chemical Properties

1. Stability: Stable at –20 °C; sensitive to high temperature, strong acids/bases
2. Reactivity: Binds TLR3/MDA5/RIG-I; induces IFN-α/β/γ and proinflammatory cytokines
3. Sterility: Sterile-filtered; no microbial contamination

Applications

1. Cancer Immunotherapy: Adjuvant for melanoma, glioblastoma, lymphoma, and solid tumors.
2. Antiviral Research: Inhibits HIV, HCV, influenza, and other viral infections via interferon induction.
3. Vaccine Adjuvant: Enhances humoral and cellular immunity in infectious disease vaccines.
4. Immune-Oncology: Activates tumor microenvironment; promotes anti-tumor immune responses.
5. Preclinical Research: Immunology, inflammation, and cancer model studies.

Storage & Transportation

Storage Conditions

• Lyophilized: Store at –20 °C, sealed, dry, protected from light.
• Reconstituted: Store at 2–8 °C for ≤7 days; avoid freeze-thaw cycles.
• Shelf Life: 24 months (unopened); 7 days after reconstitution.

Transportation

• Classified as non-hazardous.
• Ship with dry ice (–20 °C) to maintain stability.
• Avoid exposure to heat, moisture, and direct sunlight.

Handling

• Wear sterile gloves, lab coat, and safety goggles.
• Reconstitute in sterile water for injection (WFI) under aseptic conditions.
• Avoid inhalation, skin/eye contact.

Regulatory Information

• CAS No: 59789-29-6
• Synonyms: Hiltonol; Polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose
• HS Code: 3822000090
• Grade: Research Grade / GMP-Grade (for clinical trials)
• Compliance: Meets USP/EP standards; FDA IND-compliant for oncology trials

Full Product Parameter Table