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Product Overview
Tetrabutylammonium fluoride (TBAF) (CAS 429-41-4) is a quaternary ammonium fluoride salt, commonly supplied as a 1.0 M solution in THF. It is a strong fluoride ion source and mild base, widely used in organic synthesis for desilylation, nucleophilic fluorination, and phase-transfer catalysis. High solubility in organic solvents, low nucleophilicity, and stable quality. For industrial synthesis, pharmaceutical R&D, and laboratory use only.
Product Features
- High Purity: ≥98.0% (titration), low moisture (<10%), minimal impurities.
- Strong Fluoride Source: Efficient for cleavage of silyl ethers (TMS, TBDMS).
- Excellent Solubility: Miscible with THF, acetonitrile, DMSO, and most organic solvents.
- Mild Basicity: Reduces side reactions in sensitive substrates.
- Strict QC: COA/MSDS available; batch-to-batch consistency.
Physical & Chemical Properties
Physical Properties
- Appearance: Colorless to light yellow clear liquid (1M THF solution); white crystalline solid (anhydrous).
- Odor: Faint amine-like odor.
- Molecular Formula: C16H36FN
- Molecular Weight: 261.46
- Melting Point: 62–63 °C (anhydrous)
- Density: 0.953 g/mL at 25 °C (1M THF)
- Refractive Index: n20/D 1.456
- Flash Point: 1 °F (?17 °C)
- Solubility: Miscible with water, THF, acetonitrile, DMSO; insoluble in hexane.
- Hygroscopicity: Highly hygroscopic; absorbs moisture rapidly.
Chemical Properties
- Stability: Stable under inert atmosphere; decomposes at >150 °C.
- pH: Basic (pH 8–9 in aqueous solution).
- Reactivity: Reacts with strong acids, oxidizing agents, and moisture.
- Incompatibility: Avoid contact with glass (etches at high temp), strong acids, and oxidants.
Applications
- Organic Synthesis: Desilylation of silyl-protected alcohols/phenols; nucleophilic fluorination; phase-transfer catalyst (PTC) for SN2 reactions.
- Pharmaceutical R&D: Synthesis of nucleosides, carbohydrates, and fluorinated APIs.
- Material Science: Etching of silicon wafers; surface modification of silica.
- Analytical Chemistry: Ion-pair reagent for HPLC; fluoride standard solution.
- Laboratory Research: Standard reagent for desilylation and fluorination studies.
Usage Restriction: For industrial synthesis, pharmaceutical research, and laboratory use only. Not for human consumption or medical use.
Storage & Transportation
Storage Conditions
Store in cool, dry, dark place (2–8 °C recommended). Keep tightly sealed under nitrogen; avoid moisture, air, and direct sunlight. Highly hygroscopic—minimize exposure.
Transportation
Classified as corrosive (UN 2920, Class 8). Use sealed HDPE bottles or steel drums with inner liner. Avoid heavy impact, leakage, and rain. Do not ship with food, acids, or oxidants.
Handling
Wear chemical-resistant gloves, safety goggles, and lab coat. Operate in fume hood. Avoid inhalation, skin/eye contact. Rinse skin/eyes with plenty of water for 15+ minutes if contact occurs.
Regulatory Information
- CAS No: 429-41-4
- EINECS: 207-057-2
- HS Code: 29239000
- UN Number: 2920 (Corrosive liquid, basic, organic, n.o.s.)
- Grade: Synthesis Grade / Pharmaceutical Grade / Research Grade
- Compliance: Meets ACS, GMP standards; export compliant with IATA/IMDG.
Full Product Parameter Table
| Item | Specification |
| Product Name | Tetrabutylammonium fluoride |
| CAS NO. | 429-41-4 |
| Synonyms | TBAF; Tetra-n-butylammonium fluoride; 1M in THF |
| Molecular Formula | C16H36FN |
| Molecular Weight | 261.46 |
| EINECS | 207-057-2 |
| UN Number | 2920 |
| Hazard Class | 8 (Corrosive) |
| Appearance | Colorless to Light Yellow Clear Liquid (1M THF) |
| Purity | ≥98.0% (Titration) |
| Concentration | 1.0 ± 0.1 mol/L (THF) |
| Water Content | ≤10.0% |
| Melting Point | 62–63 °C (Anhydrous) |
| Density | 0.953 g/mL (25 °C, 1M THF) |
| Refractive Index | n20/D 1.456 |
| Flash Point | ?17 °C |
| Solubility | Miscible with THF, MeCN, DMSO, Water |
| Storage Temperature | 2–8 °C, Sealed, Dry, Inert Atmosphere |
| Shelf Life | 12 Months (Original Packaging) |
| Packing | 250mL/500mL/1L HDPE Bottle; 25L Steel Drum |
| Grade | Synthesis Grade / Pharmaceutical Grade / Research Grade |
| Application | Desilylation, Fluorination, Phase-Transfer Catalysis |
