Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
Ethyl difluoroacetate (CAS 454-31-9) is an important fluorinated organic ester compound. It is a colorless transparent liquid with special ester odor. Featuring high chemical activity and excellent solubility, it is widely used in pharmaceutical intermediates, pesticide synthesis, fine chemicals and organic synthesis research. Produced via professional fluorination, esterification and precision purification processes, the product has high purity, low impurities and stable batch quality. For legitimate industrial production, formulation and scientific research only.
Product Features
- High Purity: ≥99.0% (GC), meets industrial grade and research grade standards.
- High Reactivity: The difluoroalkyl group enables various organic conversion reactions.
- Good Solubility: Miscible with common organic solvents, suitable for multiple reaction systems.
- Strict Quality Control: Each batch is fully tested; standard COA and MSDS are available upon request.
Physical & Chemical Properties
Physical Properties
- Appearance: Colorless transparent liquid
- Odor: Characteristic ester odor
- Molecular Formula: C4H6F2O2
- Molecular Weight: 124.09
- Melting Point: -61 °C
- Boiling Point: 99 – 101 °C
- Density: 1.194 g/mL (20 °C)
- Refractive Index: 1.346 (20 °C)
- Flash Point: 10 °C
- Solubility: Slightly soluble in water; miscible with ethanol, ether, acetone and other organic solvents
- Hygroscopicity: Non-hygroscopic
Chemical Properties
- Chemical Stability: Stable under normal temperature and sealed conditions.
- Chemical Reactivity: Easy to undergo hydrolysis, aminolysis and condensation reactions.
- Acid-Base Character: Neutral in conventional environment.
- Incompatibility: Keep away from strong acids, strong alkalis, strong oxidants and open flame.
Applications
- Pharmaceutical Industry: Key fluorinated intermediate for synthesizing antibiotics, anti-inflammatory drugs and other pharmaceutical products.
- Pesticide Industry: Raw material for manufacturing high-efficiency fluorinated pesticides and herbicides.
- Organic Synthesis: Building block for preparing difluoro-containing compounds and fluorinated fine chemicals.
- Laboratory Research: Common reagent for fluorine chemistry and organic synthesis experiments.
Usage Restriction: For industrial synthesis and scientific research use only. Strictly forbidden for illegal processing and improper application.
Storage & Transportation Instructions
Storage Conditions
Store in a cool, dry, dark and well-ventilated warehouse. Keep containers tightly sealed. Store separately from oxidants, acids, alkalis and combustible materials. Keep far from heat sources and open flame. Recommended storage temperature: 10 – 25 °C. Reseal containers immediately after opening.
Transportation Requirements
This product is classified as flammable liquid. Adopt sealed and anti-collision packaging. Avoid violent collision, extrusion, high temperature and rain soaking during transit. Do not transport together with food, feed and toxic substances.
Operation Notes
Wear chemical-resistant gloves, safety goggles and gas mask. Operate in a well-ventilated fume hood. Avoid inhalation of vapor and direct contact with skin and eyes. Rinse thoroughly with plenty of clean water in case of contact. Do not eat, drink or smoke in the working area.
Regulatory Information
EINECS Number: 206-017-5
HS Code: 2915900090
Complies with international fluorinated chemical standards. Export products follow IATA and IMDG provisions. All transactions are limited to qualified chemical factories, pharmaceutical enterprises, pesticide manufacturers and research institutions.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | Ethyl difluoroacetate |
| CAS NO. | 454-31-9 |
| IUPAC Name | Ethyl 2,2-difluoroacetate |
| Synonyms | Difluoroacetic acid ethyl ester |
| Molecular Formula | C4H6F2O2 |
| Molecular Weight | 124.09 |
| EINECS Number | 206-017-5 |
| UN Number | UN 1993 |
| Hazard Class | Flammable Liquid, Irritant |
| Appearance | Colorless transparent liquid |
| Purity | ≥99.0% (GC) |
| Water Content | ≤0.2% |
| Melting Point | -61 °C |
| Boiling Point | 99 – 101 °C |
| Density | 1.194 g/mL (20 °C) |
| Refractive Index | 1.346 (20 °C) |
| Flash Point | 10 °C |
| Solubility | Slightly soluble in water; miscible with ethanol, ether, acetone |
| HS Code | 2915900090 |
| Storage Temperature | 10 – 25 °C, sealed, dry environment |
| Packing Specification | 25kg/plastic drum, 200kg/iron drum |
| Grade Standard | Industrial Grade / Research Grade |
| Application Scope | Fluorinated pharmaceutical intermediate, pesticide intermediate, organic synthesis reagent |
| Validity Period | 24 Months under specified storage conditions |
