Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD, CAS 128446-35-5) is a highly water-soluble β-cyclodextrin derivative modified with 2-hydroxypropyl groups. It is a white to off-white amorphous or crystalline powder. As a safe, non-toxic, and highly efficient inclusion carrier, it overcomes the poor water solubility of natural β-cyclodextrin, widely used in pharmaceutical solubilization, food stabilization, cosmetic formulation, and biomedical research. Manufactured via controlled etherification, purification, and drying processes, it features high purity, adjustable substitution degree, and stable batch quality. For legitimate pharmaceutical, food, cosmetic, and research use only.
Product Features
- Ultra-High Water Solubility: Solubility ≥50 g/100 mL (25°C), far exceeding natural β-cyclodextrin.
- Excellent Inclusion Capacity: Retains hydrophobic cavity, effectively encapsulates lipophilic molecules to enhance stability and bioavailability.
- Good Biocompatibility: Low hemolytic activity, non-irritating to muscles, suitable for injections and oral formulations.
- Adjustable Substitution Degree: Hydroxypropyl substitution degree (MS) 4–10, customizable for different applications.
- Strict Quality Control: Complies with CP/USP/EP standards; COA, MSDS, and DMF documentation available.
Physical & Chemical Properties
Physical Properties
- Appearance: White to off-white amorphous or crystalline powder
- Odor: Odorless, slightly sweet taste
- Molecular Formula: C??H???O?? (average)
- Molecular Weight: 1431–1806 (average ~1460)
- Melting Point: 267 °C (decomposition)
- Specific Rotation: [α]2?/D +135° (c=1, H?O)
- Solubility: Freely soluble in water, propylene glycol; soluble in methanol, ethanol; practically insoluble in acetone, chloroform
- pH Value (5% aqueous solution): 5.0–7.5
- Hygroscopicity: Strongly hygroscopic
Chemical Properties
- Chemical Stability: Stable under normal temperature and dry conditions; stable in pH 2–12 aqueous solutions.
- Structural Characteristics: β-cyclodextrin backbone with 2-hydroxypropyl ether substituents, retaining hydrophobic cavity.
- Inclusion Ability: Forms reversible inclusion complexes with lipophilic drugs, essential oils, and pigments.
- Incompatibility: Avoid strong oxidants, strong acids, and high-temperature environments.
Applications
- Pharmaceutical Industry: Solubilizer and stabilizer for poorly soluble drugs (e.g., Paclitaxel, Ibuprofen); enhances bioavailability, reduces toxicity; used in injections, oral formulations, and transdermal preparations.
- Food Industry: Stabilizer, emulsifier, and flavor protector; encapsulates flavors, pigments, and nutrients to prevent oxidation and volatilization.
- Cosmetic Industry: Carrier for essential oils and active ingredients; improves stability and skin permeability; used in creams, lotions, and perfumes.
- Biomedical Research: Chiral selector, drug delivery vehicle, and protein stabilizer; applied in capillary electrophoresis and drug formulation studies.
- Chemical Industry: Dispersant and additive for polymer materials, coatings, and adhesives.
Usage Restriction: For industrial synthesis and scientific research use only. Strictly forbidden for illegal processing and improper application.
Storage & Transportation Instructions
Storage Conditions
Store in a cool, dry, dark, and well-ventilated warehouse. Keep containers tightly sealed to prevent moisture absorption. Store separately from oxidants, acids, and toxic substances. Keep away from heat sources and direct sunlight. Recommended storage temperature: 10–25 °C. Reseal containers immediately after opening.
Transportation Requirements
This product is classified as non-hazardous goods. Adopt moisture-proof sealed packaging. Avoid violent collision, extrusion, and rain soaking during transit. Do not transport together with oxidants, acids, food, and feed.
Operation Notes
Wear dust mask, chemical-resistant gloves, and safety goggles. Operate in a well-ventilated area. Avoid inhalation of dust and direct contact with skin and eyes. In case of contact, rinse the affected area with plenty of clean water immediately. Do not eat, drink, or smoke in the working area.
Regulatory Information
EINECS Number: 271-490-8
HS Code: 3824999999
Complies with USP, EP, and CP standards; FDA DMF registered (DMF No. 030168). Export products follow IATA and IMDG provisions. All transactions are limited to qualified pharmaceutical enterprises, food factories, cosmetic manufacturers, and licensed research institutions.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | (2-Hydroxypropyl)-β-cyclodextrin |
| CAS NO. | 128446-35-5 |
| IUPAC Name | β-Cyclodextrin, 2-hydroxypropylether |
| Synonyms | HP-β-CD; Hydroxypropyl betadex; CAVASOL® W7 HP |
| Molecular Formula | C??H???O?? (average) |
| Molecular Weight | 1431–1806 (average ~1460) |
| EINECS Number | 271-490-8 |
| UN Number | Non-hazardous goods |
| Hazard Class | None |
| Appearance | White to off-white amorphous or crystalline powder |
| Purity | ≥98.0% (dry basis) |
| Hydroxypropyl Content | 19.6%–26.3% (anhydrous) |
| Water Content | ≤10.0% |
| Melting Point | 267 °C (Decomposition) |
| Specific Rotation | [α]2?/D +135° (c=1, H?O) |
| Solubility | ≥50 g/100 mL in water (25°C) |
| pH (5% Solution) | 5.0–7.5 |
| HS Code | 3824999999 |
| Storage Temperature | 10–25 °C, sealed, dry environment |
| Packing Specification | 1kg/5kg/aluminum foil bag, 25kg/fiber drum |
| Grade Standard | Pharma Grade / Food Grade / Cosmetic Grade / Research Grade |
| Application Scope | Drug solubilizer, food stabilizer, cosmetic carrier, research reagent |
| Validity Period | 24 Months under specified storage conditions |
