Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
Etoposide (CAS 33419-42-0) is a semi-synthetic podophyllotoxin derivative with potent antitumor activity. It appears as white to off-white crystalline powder. As a classic chemotherapeutic API, it acts by inhibiting topoisomerase II to block cell division and induce tumor cell apoptosis. This product is widely applied in pharmaceutical manufacturing, oncology research and analytical testing fields. Produced via sophisticated extraction, synthesis and purification processes, it features high purity, stable chemical properties and reliable batch consistency. For legitimate industrial production, formulation and scientific research only.
Product Features
- High Purity: HPLC ≥98.0% / ≥99.0%, low related impurities, meets pharmacopoeia standards.
- Unique Antitumor Mechanism: Specifically inhibits DNA topoisomerase II, showing broad-spectrum anti-cancer effects.
- Good Liposolubility: Dissolves well in common organic solvents, adaptable to multiple pharmaceutical formulations.
- Stable Structure: Maintains stable biological activity under recommended storage conditions.
- Strict Quality Control: Each batch is fully tested; standard COA and MSDS are available upon request.
Physical & Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Molecular Formula: C29H32O13
- Molecular Weight: 588.56
- Melting Point: 236 – 251 °C (decomposition)
- Specific Rotation: [α]2?/D ?110° ~ ?116° (c=1, Chloroform)
- Solubility: Slightly soluble in water; soluble in ethanol, methanol, DMSO and chloroform
- Hygroscopicity: Slightly hygroscopic
Chemical Properties
- Chemical Stability: Stable in sealed, dry and dark environment. Gradually decomposes and loses activity under prolonged exposure to high temperature and strong light.
- Structural Characteristics: Contains multiple hydroxyl groups, lactone ring and aromatic ring in the molecular structure.
- Chemical Reactivity: Hydroxyl groups can undergo esterification and etherification reactions under specific conditions.
- Incompatibility: Keep away from strong oxidants, strong acids, strong alkalis and direct sunlight.
Applications
- Pharmaceutical Industry: Core anti-tumor API, mainly used for the treatment of small cell lung cancer, testicular cancer, lymphoma and other malignant tumors.
- Biomedical Research: Applied in oncology mechanism research, cell cycle study and anti-tumor drug screening experiments.
- Analytical Chemistry: Used as reference standard for chromatographic qualitative and quantitative detection of antitumor drugs.
- Preclinical Research: Widely used in animal model experiments for tumor therapy research.
Usage Restriction: For industrial synthesis and scientific research use only. Strictly forbidden for illegal processing and improper application.
Storage & Transportation Instructions
Storage Conditions
Store in a cool, dry, dark and well-ventilated warehouse. Keep containers tightly sealed to prevent moisture absorption and photodegradation. Store separately from strong oxidants, acids and alkalis, and keep far from heat sources and direct sunlight. Recommended storage temperature: 2 – 8 °C. Reseal containers immediately after opening.
Transportation Requirements
This product is classified as non-hazardous goods. Adopt sealed and light-proof packaging. Avoid violent collision, extrusion and rain soaking during transit. Do not transport together with corrosive chemicals, oxidants, food and feed. Comply with relevant regulations for pharmaceutical raw materials.
Operation Notes
Wear dust mask, chemical-resistant gloves and safety goggles. Conduct all operations in a well-ventilated fume hood. Avoid inhalation of dust and direct contact with skin and eyes. In case of accidental contact, rinse the affected area with plenty of clean water immediately. Do not eat, drink or smoke in the working area.
Regulatory Information
EINECS Number: 251-502-1
HS Code: 2938909090
Comply with USP, EP and related international pharmaceutical standards. Export products follow IATA and IMDG provisions. All transactions are limited to qualified pharmaceutical enterprises, professional laboratories and licensed research institutions.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | Etoposide |
| CAS NO. | 33419-42-0 |
| IUPAC Name | (5R,5aR,8aR,9R)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-yl 4,6-O-(R)-ethylidene-β-D-glucopyranoside |
| Synonyms | Etoposid; VP-16; Etopol |
| Molecular Formula | C29H32O13 |
| Molecular Weight | 588.56 |
| EINECS Number | 251-502-1 |
| UN Number | Non-hazardous goods |
| Hazard Class | None |
| Appearance | White to off-white crystalline powder |
| Purity | HPLC ≥98.0% / ≥99.0% |
| Water Content | ≤0.5% |
| Melting Point | 236 – 251 °C (Decomposition) |
| Specific Rotation | [α]2?/D ?110° ~ ?116° (c=1, Chloroform) |
| Solubility | Slightly soluble in water; soluble in ethanol, DMSO and chloroform |
| HS Code | 2938909090 |
| Storage Temperature | 2 – 8 °C, sealed, dry & dark environment |
| Packing Specification | 1g/5g/10g/amber glass bottle, 25g/100g/aluminum foil bag, 1kg/fiber drum |
| Grade Standard | Pharma Grade / Research Grade / Analytical Standard |
| Application Scope | Antitumor API, oncology research reagent, chromatographic reference standard |
| Validity Period | 24 Months under specified storage conditions |
