Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, commonly known as EDC·HCl or EDC hydrochloride, is a water-soluble carbodiimide coupling agent. It appears as white crystalline powder with slight characteristic odor. With excellent amide and ester bond forming ability, it is widely used for cross-linking and conjugation of proteins, peptides, nucleic acids and organic molecules. This product serves as a key reagent in biochemistry, pharmaceutical synthesis, immunology and material science. Manufactured via refined synthesis and recrystallization processes, it features high purity, low impurity content and stable activity. For legitimate industrial production, formulation and scientific research only.
Product Features
- Water Solubility: Fully soluble in water and aqueous buffer solutions, convenient for aqueous phase reaction systems.
- Efficient Coupling Performance: Rapidly promotes condensation reaction between carboxylic acids and amines to form stable amide bonds under mild conditions.
- Mild Reaction Condition: Works effectively at room temperature and neutral to weak alkaline environment, hardly causing denaturation of biological samples.
- High Purity & Activity: Low content of residual impurities, maintains stable coupling activity during storage.
- Wide Compatibility: Compatible with most biological reagents and common organic solvents, suitable for various synthesis and experimental schemes.
- Strict Quality Control: Every batch is strictly tested; standard COA and MSDS are available upon request.
Physical & Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Slight characteristic amine odor
- Molecular Formula: C8H18ClN3
- Molecular Weight: 191.70
- Melting Point: 110 – 114 °C
- Solubility: Freely soluble in water, methanol and ethanol; soluble in polar organic solvents; insoluble in non-polar solvents
- pH (1% aqueous solution): 4.0 – 6.0
- Hygroscopicity: Highly hygroscopic
Chemical Properties
- Chemical Stability: Stable in sealed, dry and cool environment. Easy to absorb moisture and gradually hydrolyze when exposed to air.
- Acid-Base Character: Weakly acidic aqueous solution.
- Core Reaction: Acts as a zero-length crosslinker, activates carboxyl groups to react with amino groups, hydroxyl groups to generate amides and esters.
- Hydrolysis Property: Hydrolyzes in water to form urea derivatives and dimethylaminopropylamine, resulting in activity decline.
- Incompatibility: Keep away from strong oxidants, strong acids, strong alkalis and moisture.
Applications
- Biochemical Research: Classic coupling reagent for peptide synthesis, protein cross-linking and antibody labeling; widely used in enzyme immobilization and biomolecular conjugation.
- Pharmaceutical Industry: Key intermediate and condensing agent for the synthesis of peptide drugs, amino acid derivatives and biological preparations.
- Immunology & Diagnostics: Used for preparing antigen-antibody conjugates and diagnostic reagents in immunodetection products.
- Organic Synthesis: Condensing agent for synthesizing amides, esters and heterocyclic compounds in fine chemical production.
- Material Science: Applied for surface modification of polymer materials and preparation of functional composite materials.
Usage Restriction: For industrial synthesis and scientific research use only. Strictly forbidden for illegal processing and improper application.
Storage & Transportation Instructions
Storage Conditions
Store in a cool, dry, dark and well-ventilated warehouse. Keep containers tightly sealed to prevent moisture absorption and hydrolysis. Store separately from strong oxidants, acids and alkalis, and stay away from heat sources and direct sunlight. Recommended storage temperature: 2 – 8 °C. Reseal containers immediately after opening.
Transportation Requirements
This product is classified as non-hazardous goods. Adopt moisture-proof sealed packaging with desiccant inside. Avoid violent collision, extrusion and rain soaking during transit. Do not transport together with corrosive chemicals, food and feed.
Operation Notes
Wear dust mask, chemical-resistant gloves and safety goggles. Conduct all operations in a well-ventilated fume hood. Avoid inhalation of dust and direct contact with skin and eyes. In case of contact, rinse the affected area with plenty of clean water immediately. Do not eat, drink or smoke in the working area.
Regulatory Information
EINECS Number: 247-361-2
HS Code: 2921590090
Comply with international chemical safety standards. Export products follow IATA and IMDG regulations. All transactions are limited to qualified chemical factories, pharmaceutical enterprises, biological laboratories and research institutions.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride |
| CAS NO. | 25952-53-8 |
| IUPAC Name | N'-ethyl-N-(3-dimethylaminopropyl)carbodiimide hydrochloride |
| Synonyms | EDC HCl; EDAC; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride |
| Molecular Formula | C8H18ClN3 |
| Molecular Weight | 191.70 |
| EINECS Number | 247-361-2 |
| UN Number | Non-hazardous goods |
| Hazard Class | None |
| Appearance | White crystalline powder |
| Purity | ≥99.0% |
| Water Content | ≤1.0% |
| Melting Point | 110 – 114 °C |
| pH (1% Solution) | 4.0 – 6.0 |
| Solubility | Freely soluble in water, methanol and ethanol |
| HS Code | 2921590090 |
| Storage Temperature | 2 – 8 °C, sealed, dry & dark environment |
| Packing Specification | 10g/25g/100g/glass bottle, 1kg/aluminum foil bag, 25kg/fiber drum |
| Grade Standard | Biochemical Grade / Synthesis Grade / Research Grade |
| Application Scope | Coupling agent, peptide synthesis reagent, protein crosslinker, pharmaceutical intermediate |
| Validity Period | 24 Months under specified storage conditions |
