Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
Esmolol Hydrochloride (CAS 81161-17-3) is an ultra-short acting and selective β1-adrenergic receptor blocker. It appears as white to off-white crystalline powder with excellent water solubility. This pharmaceutical raw material features rapid onset, short half-life and quick reversibility after drug withdrawal. It is widely applied for the control of heart rate and blood pressure in emergency treatment and perioperative period. Manufactured in accordance with GMP guidelines and pharmacopoeia standards, our product has high purity, low impurities and stable batch consistency. This product is only for legitimate pharmaceutical formulation and scientific research. Unauthorized human use and illegal processing are strictly prohibited.
Product Features
- High Purity Grade: HPLC ≥98.0% / ≥99.0%, related substances and impurities are strictly controlled.
- Ultra-short Acting Property: Onset of action within 1–2 minutes after administration, half-life about 9 minutes, effects fade rapidly after discontinuation for high safety.
- Cardiac Selectivity: Preferentially acts on β1 receptors, with minimal impact on bronchial β2 receptors at therapeutic doses.
- Good Solubility: Highly soluble in water and ethanol, ideal for the preparation of injection formulations.
- Strict Quality Management: Each batch is fully tested; standard COA, MSDS and relevant documents can be provided.
Physical & Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: 48 – 50 °C
- Density: 1.15 g/cm3 (25 °C)
- Solubility: Freely soluble in water and ethanol; soluble in methanol; slightly soluble in common organic solvents
- Bulk Density: 0.45 – 0.65 g/cm3
Chemical Properties
- Chemical Stability: Stable under sealed, cool and dry conditions at room temperature. Avoid long-term exposure to strong light and high temperature.
- Acid-Base Character: Weakly acidic in aqueous solution.
- Reactivity: Stable under normal storage; avoid contact with strong oxidants and strong alkalis which may cause structural degradation.
- Hygroscopicity: Slightly hygroscopic, keep tightly sealed to prevent moisture absorption.
- Incompatibility: Incompatible with strong oxidizing agents, strong bases and corrosive chemicals.
Applications
- Pharmaceutical Industry: Key API for preparing intravenous injections, mainly used to treat tachycardia, hypertension and arrhythmia during perioperative period and emergency medical treatment.
- Biomedical Research: Standard reagent for cardiovascular pharmacology research and related pharmacological experiments.
- Fine Chemicals: Intermediate for the synthesis of β-receptor antagonist derivatives.
Usage Restriction: For pharmaceutical production and scientific research only. Strictly forbidden for illegal production, counterfeit drugs and improper application.
Storage & Transportation Instructions
Storage Conditions: Store in a cool, dry and well-ventilated warehouse. Keep container tightly sealed, away from direct sunlight, heat sources and moisture. Recommended storage temperature: 10 – 25 °C.
Transportation Requirements: Transport as general pharmaceutical chemicals. Avoid violent collision, extrusion and rain wetting. Do not transport together with oxidants, alkalis and toxic substances.
Operation Notes: Wear chemical-resistant gloves, safety goggles and dust mask. Work in a well-ventilated area. Avoid inhalation of powder and direct contact with skin and eyes.
Regulatory Information
This product is a prescription pharmaceutical active ingredient, compliant with USP, EP and other international pharmacopoeia standards. Domestic sales and cross-border export must comply with local drug supervision laws. All transactions are limited to qualified pharmaceutical manufacturers and professional research institutions.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | Esmolol Hydrochloride |
| CAS NO. | 81161-17-3 |
| IUPAC Name | Methyl 4-[2-hydroxy-3-(propan-2-ylamino)propoxy]hydrocinnamate hydrochloride |
| Synonyms | Esmolol HCl |
| Molecular Formula | C16H28ClNO4 |
| Molecular Weight | 333.85 |
| EINECS Number | 279-702-4 |
| UN Number | Non-dangerous goods |
| Appearance | White to off-white crystalline powder |
| Purity | HPLC ≥98.0% / ≥99.0% (customizable) |
| Melting Point | 48 – 50 °C |
| Density | 1.15 g/cm3 (25 °C) |
| Solubility | Freely soluble in water and ethanol |
| HS Code | 2922509090 |
| Storage Temperature | 10 – 25 °C, sealed, dry & dark environment |
| Packing Specification | 1kg/aluminum foil bag, 25kg/fiber drum (Inner PE bag) |
| Grade Standard | Pharma Grade / Research Grade |
| Application Scope | Cardiovascular API, anti-arrhythmia raw material, pharmacological research reagent |
| Validity Period | 24 Months under specified storage conditions |
