Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Product Overview
Letrozole (CAS 112809-51-5) is a high-purity non-steroidal aromatase inhibitor, also known as 1-[Bis(4-cyanophenyl)methyl]-1,2,4-triazole or 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile. It appears as a white to off-white crystalline powder, with stable chemical structure and high biological activity. As a key pharmaceutical intermediate and anti-tumor raw material, it is widely used in breast cancer treatment and related scientific research. Our product is produced under strict GMP-compliant quality control, featuring high purity, low impurities and stable batch consistency. For industrial synthesis and scientific research only; not for human consumption or unauthorized medical use.
Product Features
- High Purity Grade: Available in HPLC ≥98.0% and ≥99.0% grades, with strict control of related impurities and moisture.
- Stable Physical Properties: White crystalline powder; stable under normal temperature and sealed conditions, not easy to decompose.
- High Biological Activity: Potent and selective aromatase inhibitor (IC50 ≈1–2 nM), effectively inhibiting estrogen synthesis.
- Strict Quality Inspection: Each batch tested via HPLC, melting point and moisture analysis; COA provided upon request.
- Professional Low-Temp Packaging: Sealed and moisture-proof packaging to ensure stability during storage and transportation.
Applications
- Pharmaceutical Industry: Key raw material for anti-breast cancer drugs, used in endocrine therapy for postmenopausal hormone receptor-positive breast cancer.
- Biomedical Research: Standard reagent for tumor biology, endocrinology and pharmacology research; used in estrogen-dependent disease studies.
- Fine Chemicals: Intermediate for synthesizing other nitrogen-containing heterocyclic compounds and pharmaceutical derivatives.
- Usage Restriction: For industrial/research use only. Not for food, feed, cosmetics or illegal drug manufacturing.
Storage & Transportation Instructions
Storage Conditions: Store in a cool, dry, well-ventilated warehouse. Keep tightly sealed, protected from light, high temperature and moisture. Recommended storage temperature: 2–8°C (refrigerated storage for long-term preservation).
Transportation Requirements: Classified as non-dangerous goods for general transport. Avoid violent collision, extrusion and direct sunlight. Keep away from strong oxidants and acids during transit.
Operation Notes: Wear chemical-resistant gloves, safety goggles and dust mask. Operate in a well-ventilated fume hood. Avoid inhalation, skin and eye contact.
Regulatory Information
This product is a prescription pharmaceutical intermediate, subject to strict international drug control regulations. Domestic sales and cross-border export must comply with local laws and regulations. All transactions are limited to legitimate pharmaceutical production and scientific research institutions. Any illegal use or resale is prohibited.
Full Product Parameter Table
| Item | Specification & Details |
| Product Name | Letrozole |
| CAS NO. | 112809-51-5 |
| IUPAC Name | 1-[Bis(4-cyanophenyl)methyl]-1,2,4-triazole |
| Synonyms | 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile; Femara |
| Molecular Formula | C17H11N5 |
| Molecular Weight | 285.30 |
| EINECS Number | 675-034-8 |
| Appearance | White to off-white crystalline powder |
| Purity | HPLC ≥98.0% / ≥99.0% (customizable) |
| Melting Point | 181–183°C |
| Boiling Point | 563.5±60.0°C (Predicted) |
| Density | 1.21±0.1 g/cm3 (Predicted) |
| Refractive Index | 1.615 |
| Flash Point | 214.2±24.5°C |
| Solubility | Slightly soluble in water; soluble in DMSO (>50mg/mL), methanol, ethanol |
| HS Code | 2933990090 |
| Storage Temperature | 2–8°C, sealed, dry & dark environment |
| Packing Specification | 1kg/bottle, 5kg/box, 25kg/drum (Inner PE bag) |
| Grade Standard | Pharmaceutical Intermediate Grade / Research Grade |
| Application Scope | Anti-tumor Drug Intermediate, Breast Cancer Treatment, Biomedical Research |
| Validity Period | 24 Months under specified storage conditions |
