Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.

CAS：202409-33-4

Molecular Formula：C??H??ClN?O?S

Molecular Weight：358.84

Alias：MK-0663; Arcoxia; Nucoxia; 

Category：Selective COX-2 inhibitor, non-steroidal anti-inflammatory drug (NSAID)

Physical Properties

• Appearance：White to pale yellow crystalline powder
• Solubility：Practically insoluble in water (3.28e-03 g/L); soluble in DMSO
• Melting Point：134–135℃
• Boiling Point：510±50℃ (760 mmHg)
• Density：1.298±0.06 g/cm3
• LogP：5.26; PSA：68.3 ?2
• Storage：Inert atmosphere, 2–8℃, protected from light

Specification Sheet

Main Application

• Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
• Acute gouty arthritis (120 mg once daily, max 8 days)
• Postoperative pain and primary dysmenorrhea
  Mechanism: Selectively inhibits COX-2 (IC50=1.1 μM) over COX-1 (IC50=116 μM), reducing GI side effects while suppressing inflammation and pain.