Aminophylline
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
420.43
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
Product Name: Aminophylline
Alias: Theophylline ethylenediamine, (Theophylline)?·Ethylenediamine, Aminodur, Cariomin
CAS No: 317-34-0
Molecular Formula: C??H??N??O? (anhydrous)
Molecular Weight: 420.43
EINECS: 206-264-5
Classification: Xanthine derivative, bronchodilator, anti-asthmatic API
Structure
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder or granules, slightly ammonia odor, easy caking
- Melting Point: 269–270°C
- Boiling Point: 454.1°C (760 mmHg)
- Solubility: Soluble in water (~50 mg/mL, fresh prep.); sparingly soluble in ethanol; practically insoluble in ether
- Stability: Stable at RT; absorbs CO? in air, decomposes to theophylline; unstable in acid
- pKa: ~5.0
- Storage: 2–8°C, sealed, protect from light; avoid moisture
Specification Table (Pharmaceutical Grade)
| Item | Specification | Unit | Remarks |
| Product Name | Aminophylline | - | API |
| CAS No | 317-34-0 | - | 317-34-0 |
| Appearance | White to off-white powder | - | Slight ammonia smell |
| Molecular Formula | C??H??N??O? | - | Anhydrous |
| Molecular Weight | 420.43 | g/mol | - |
| Purity | ≥98.0 | % | HPLC |
| Theophylline Content | 84.0–87.4 | % | By assay |
| Ethylenediamine Content | 13.5–15.0 | % | By assay |
| Moisture | ≤0.5 | % | Karl Fischer |
| Heavy Metals | ≤10 | ppm | Pb |
| Residue on Ignition | ≤0.1 | % | - |
Main Uses
- Bronchodilator: Relaxes airway smooth muscle, treats asthma, COPD, bronchospasm
- Respiratory disorders: Chronic bronchitis, emphysema, neonatal apnea
- Cardiac & diuretic: Stimulates myocardium, increases renal blood flow; adjunct for congestive heart failure, pulmonary edema
- Veterinary use: Common in equine/canine respiratory conditions
Mode of Action
- Non-selective phosphodiesterase (PDE) inhibitor → ↑cAMP → smooth muscle relaxation
- Blocks adenosine receptors → bronchodilation & CNS/cardiac stimulation
