Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.

Basic Information

Physical & Chemical Properties

• Appearance: White to off-white crystalline powder
• Odor: Odorless
• Melting Point: ~68–70 °C
• Solubility: Insoluble in water; soluble in methanol, DMSO, acetonitrile (slightly)
• Stability: Stable under dry & ambient conditions; light-sensitive, store sealed & dark
• IC50 (Human pancreatic lipase): 5.95 nM (potent inhibitor)

Specification Table

Main Uses

1. Anti-obesity drug (API) — Potent, selective gastrointestinal/pancreatic lipase inhibitor; blocks triglyceride breakdown → reduces fat absorption → weight management.
2. Hyperlipidemia treatment — Lowers serum triglycerides; for mixed hyperlipidemia & obesity-related metabolic disorders.
3. Diabetes + obesity — Approved in Japan (2013, brand Oblean); Phase III in US; suitable for diabetic & non-diabetic obese patients.
4. Research reagent — Tool for lipase study, obesity & metabolic syndrome research; impurity reference standard.

Mechanism of Action

• Covalently binds active serine site of gastric/pancreatic lipases → enzyme deactivation.
• Triglycerides not hydrolyzed → unabsorbed, excreted in feces → reduced calorie intake & body weight.

Packaging & Storage

• Packaging: 1g/5g/25g/100g foil bag; 1kg aluminum can
• Storage: 2–8 °C; sealed, dry, dark; away from moisture/strong light