2-Ketoglutaric acid-Shandong Huashang Chemical Co., Ltd.

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2-Ketoglutaric acid

Brand：HS

Model：25kg/drum

Purity：99%

Cas：328-50-7

Createtime： 2026-04-14
Updatetime： 2026-04-15

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Product Details

useage	Industrial use
deliveryInfo
appearance	powder
Molecular Weight	146.10
aliasen
supplyCapacity	50000MT/Month
harbor	Qingdao,China
minorder	1KG
Appearance	White to off-white crystalline powder

Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.

Basic Information

Product Name: 2-Ketoglutaric acid

Alias: α-Ketoglutaric acid; 2-Oxoglutaric acid; 2-Oxopentanedioic acid; α-Ketoglutarate; Oxoglutaric acid; Alpha-ketoglutaric acid; MFCD00004165; PubChem: 51; ChEBI: 30915; RTECS: MA8050000; UNII: 737C4K198P

CAS No.: 328-50-7

EINECS No.: 206-330-3

Molecular Formula: C?H?O?

Molecular Weight: 146.10 g/mol

Classification: Organic compound, organic acid, Krebs cycle intermediate, biochemical reagent, pharmaceutical intermediate, food additive, nutritional supplement, fine chemical, research reagent

Physical & Chemical Properties

Appearance: White to off-white crystalline powder, odorless; stable under normal conditions, easily decomposes when heated, prone to decarboxylation; incompatible with strong oxidizing agents and strong bases; highly hygroscopic, turns pale yellowish-gray upon long-term storage; may cause skin, eye and respiratory irritation.

Density: 1.54 g/cm3 (25℃, predicted); LogP: -0.9 (predicted); PSA: 91.7; precise mass: 146.0266; molar refractive index: 28.37; polarizability: 11.24×10?2? cm3; surface tension: 67.9 dyne/cm.

Melting Point: 110-117℃ (lit.); decomposes when heated above melting point, easy to decarboxylate with heat.

Boiling Point: 345.6±25.0℃ (predicted, atmospheric pressure); decomposes before boiling if heated rapidly; sublimes under reduced pressure.

Solubility: Easily soluble in water, ethanol and methanol; very slightly soluble in ether; soluble in dilute acids and alkalis; 10% aqueous solution is clear to slightly turbid, colorless or almost colorless.

Flash Point: 177.0±19.7℃ (predicted); Vapor Pressure: 0.0±0.8 mmHg (25℃, predicted); pKa: 2.45 and 4.49 (25℃); loss on drying ≤1.0% (60℃, 1 hour).

Purity: ≥97.5% (industrial grade); ≥98.0% (analytical grade, titration/HPLC); ≥99.0% (high-purity grade, for research and cell culture use).

Storage Condition: Sealed, stored in a cool and dry place at 2-8℃, protected from light and moisture; keep container tightly closed; avoid high temperature and contact with oxidizing agents and strong bases; powder can be stored at -20℃ for 2 years, and stored in solvent at -80℃ for 1 year; avoid repeated freeze-thaw cycles.

Main Uses

Biochemical & Research Field: As a key intermediate of the Krebs cycle (tricarboxylic acid cycle), it is used to study cellular energy metabolism, enzyme kinetics and metabolic pathway analysis; serves as a reversible inhibitor of tyrosinase (IC50=15 mM) and a co-substrate of 2-oxoglutarate-dependent dioxygenases; used as a biochemical reagent and reference substance for laboratory research.
Pharmaceutical & Intermediate Field: As a pharmaceutical intermediate for the synthesis of complex drug molecules; used in the preparation of reagents for liver function testing; has anti-cyanide effect, and can improve anti-cyanide ability when used in combination with sodium nitrite and sodium thiosulfate; helps reduce the body consumption of postoperative patients and long-term patients.
Food & Nutrition Field: Used as a food nutritional fortifier and ingredient in sports nutrition drinks; as a nutritional supplement, it promotes protein synthesis, maintains the body's nitrogen balance, and supports muscle health; also used as a raw material for dietary supplements.
Other Fields: Applied in cell culture (suitable for mammalian and insect cell culture) as a medium supplement; used in the production of cosmetics as a raw material; used in agriculture and animal husbandry to promote livestock growth and increase bone density; used as an organic intermediate in chemical synthesis.

Specification Table

Item	Specification	Unit	Remarks
Product Name	2-Ketoglutaric acid	—	Alias: α-Ketoglutaric acid, 2-Oxoglutaric acid
CAS Number	328-50-7	—	TSCA listed; hygroscopic; Krebs cycle intermediate
Molecular Formula	C?H?O?	—	Linear formula: HO?CCH?CH?COCO?H; IUPAC: 2-Oxopentanedioic acid
Molecular Weight	146.10	g/mol
Appearance	White to off-white crystalline powder	—	Odorless; highly hygroscopic; turns pale yellowish-gray on long storage
Melting Point	110-117	℃	lit. = literature value; decomposes and decarboxylates when heated
Purity	≥98.0	%	Analytical grade; titration/HPLC; suitable for research use