Ambrisentan-Shandong Huashang Chemical Co., Ltd.

Product

Current Position： Home > Product >Pharmaceutical Chemicals >Ambrisentan

Ambrisentan

Brand：HS

Model：25kg/drum

Purity：99%

Cas：177036-94-1

Createtime： 2026-04-14
Updatetime： 2026-04-15

Send Message

Product Details

useage	Industrial use
deliveryInfo
appearance	powder
Molecular Weight	378.42
aliasen
supplyCapacity	50000MT/Month
harbor	Qingdao,China
minorder	1KG
Appearance	White to beige crystalline powder

Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.

Basic Information

Product Name: Ambrisentan

Alias: (+)-(2S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid; Letairis®;

CAS No.: 177036-94-1

EINECS No.: NA

Molecular Formula: C??H??N?O?

Molecular Weight: 378.42 g/mol

Classification: Pharmaceutical raw material, endothelin ETA receptor antagonist, pulmonary arterial hypertension agent, fine chemical, pharmaceutical intermediate

Physical & Chemical Properties

Appearance: White to beige crystalline powder, odorless

Density: 1.228 g/cm3 (Predicted)

Melting Point: ＞150℃ (dec.)

Solubility: Slightly soluble in water; soluble in DMSO; slightly soluble in methanol; insoluble in ethanol

Optical Rotation: (+160) to (+190)°, c=0.5 in methanol

Purity: ≥98.0% (HPLC), ≥99.0% (pharmaceutical grade)

Storage Condition: Sealed, -20℃ or 2-8℃, cool and dry place, protect from light; avoid high temperature, moisture and direct sunlight; keep container tightly closed

Main Uses

Pharmaceutical Field: Used as a selective endothelin ETA receptor antagonist, mainly used in the treatment of pulmonary arterial hypertension (WHO Group 1), to improve exercise tolerance and delay clinical deterioration; it is highly selective for ETA receptors, with little activity against ETB receptors in human therapeutic doses[2][4]
Medical Research: Used as a biochemical reagent and standard substance for studying the mechanism of pulmonary arterial hypertension and the function of endothelin receptors; used in the development, detection and efficacy evaluation of related drugs; applied in cell and animal experiments to explore the related pharmacological effects[4]
Other Fields: Used as a pharmaceutical intermediate for the synthesis of related derivatives; used as a research reagent in molecular biology and pharmacology research, and is strictly prohibited for human use[5]

Specification Table

Item	Specification	Unit	Remarks
Product Name	Ambrisentan	—
CAS Number	177036-94-1	—
Molecular Formula	C??H??N?O?	—
Molecular Weight	378.42	g/mol
Appearance	White to beige crystalline powder	—
Purity	≥98.0	%	HPLC
Melting Point	＞150 (dec.)	℃	dec. = decomposition