4-Chlorobutyryl chloride-Shandong Huashang Chemical Co., Ltd.

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4-Chlorobutyryl chloride

Brand：HS

Model：25kg/drum

Purity：99%

Cas：4635-59-0

Createtime： 2026-04-14
Updatetime： 2026-04-15

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Product Details

useage	Industrial use
deliveryInfo
appearance	liquid
Molecular Weight	140.99
aliasen
supplyCapacity	50000MT/Month
harbor	Qingdao,China
minorder	1KG
Appearance	Colorless to pale yellow transparent liquid

Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.

Basic Information

Product Name: 4-Chlorobutyryl chloride

Alias: γ-Chlorobutyryl chloride; 4-Chlorobutanoyl chloride; Chlorobutyryl chloride; 4-Chloro-butyryl chloride; Cl(CH?)?COCl; MFCD00000754; Reaxys Registry Number: 773860; PubChem Substance ID: 87565889

CAS No.: 4635-59-0

EINECS No.: 225-059-1

Molecular Formula: C?H?Cl?O

Molecular Weight: 140.99 g/mol

Classification: Organic intermediate, pharmaceutical intermediate, agrochemical intermediate, acyl chloride compound, fine chemical, bifunctional organic reagent

Physical & Chemical Properties

Appearance: Colorless to pale yellow or pale yellowish-red transparent liquid, with a pungent odor; hydrolyzes in the presence of water, stable under normal dry conditions

Density: 1.26±0.01 g/cm3 (20 °C, actual measurement), 1.262 g/cm3 (20 °C, reference value)

Melting Point: -47 °C (lit.)

Boiling Point: 173-174 °C (lit., normal pressure); 68 °C at 16.00 hPa; 69-71 °C at 1.4 kPa

Vapor Pressure: Undetermined at 25 °C; flammable liquid with certain volatility

Refractive Index: 1.46±0.01 (predicted), 1.461-1.4625 (actual measurement reference)

Flash Point: 72 °C (lit.)

Solubility: Slightly soluble in water (hydrolyzes when in contact with water), soluble in ether, ethanol, acetone, toluene and other common organic solvents; compatible with most organic reaction media

Purity: ≥98.0% (GC), ≥97.0% available for industrial grade; purity can also be determined by silver nitrate titration (≥98.0%)

Storage Condition: Sealed, dry and dark place; room temperature storage is acceptable, recommended storage below 15 °C in a cool and dark place for long-term preservation; filled with inert gas (nitrogen) for better preservation; avoid moisture (causes hydrolysis), high temperature, open flame, strong oxidants and incompatible substances; store in a well-ventilated area, keep container tightly closed, lock up for storage

Main Uses

Pharmaceutical Field: As a key pharmaceutical intermediate, it is widely used in the synthesis of active pharmaceutical ingredients (APIs). It is used in the production of antipsychotic drugs such as haloperidol and tricloperidol, antihistamines such as fexofenadine, antiepileptic drugs such as levetiracetam, and antitumor antibiotics such as mitomycin C analogs. Its bifunctional reactivity (acyl chloride group and terminal alkyl chloride) makes it an important building block for synthesizing complex pharmaceutical molecules.
Agrochemical Field: Used as an intermediate in the synthesis of agrochemicals, it is a key raw material for the plant growth regulator trinexapac-ethyl, and can also be used in the synthesis of herbicides and pesticides, playing an important role in agricultural production.
Other Fields: As an important bifunctional reagent in organic synthesis, it is used in acylation reactions (acylating amines to form amides) and can be used to introduce a four-carbon chain for further functionalization or synthesis of heterocyclic compounds. It is also used as a chemical reagent in laboratory research and development, and in the production of custom fine chemicals.

Specification Table

Item	Specification	Unit	Remarks
Product Name	4-Chlorobutyryl chloride	—
CAS Number	4635-59-0	—	EINECS: 225-059-1; MFCD00000754
Molecular Formula	C?H?Cl?O	—	Acyl chloride compound (bifunctional organic reagent)
Molecular Weight	140.99	g/mol
Appearance	Colorless to pale yellow transparent liquid	—	Pungent odor; hydrolyzes in contact with water
Purity	≥98.0 (≥97.0 available)	%	GC; ≥98.0% by silver nitrate titration
Melting Point	-47	℃	lit.
Solubility	Slightly soluble in water, soluble in ether, ethanol	—	Hydrolyzes in water; compatible with most organic solvents