Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Basic Information
- Product Name: 2-(Trifluoromethyl)benzoic acid
- CAS Number: 433-97-6
- Molecular Formula: C?H?F?O?
- Molecular Weight: 190.12 g/mol
- Synonyms: α,α,α-Trifluoro-o-toluic Acid; 2-Carboxybenzotrifluoride; o-(Trifluoromethyl)benzoic acid; 2-Trifluoromethylbenzoic acid
- Classification: Aromatic carboxylic acid, fluorinated organic compound, pharmaceutical intermediate, agrochemical intermediate, fine chemical raw material
Physical & Chemical Properties
- Appearance: White crystalline powder; odorless; uniform in texture, no visible impurities; easy to agglomerate when exposed to moisture.
- Melting Point: 107-112°C; stable melting range, no decomposition during melting process, melting point range ≤2°C for high-purity products.
- Boiling Point: 243.7-247°C (760 mmHg); slight distillation at high temperature, no obvious decomposition under normal boiling pressure.
- Density: 1.4±0.1 g/cm3 (20°C); stable under normal temperature and pressure, consistent with the characteristics of fluorinated aromatic compounds.
- Refractive Index: 1.475 (20°C); stable under standard test conditions, applicable to liquid state after melting.
- Flash Point: 101.2±27.3°C; belongs to flammable solid, needs to be away from fire sources during storage and use.
- Solubility: Insoluble in water; easily soluble in ethanol, methanol, DMSO, acetone, ethyl acetate and other organic solvents; slightly soluble in petroleum ether.
- Stability: Stable under normal temperature and pressure; light-sensitive, easy to decompose when exposed to strong light; hygroscopic, avoid long-term exposure to humid environment; incompatible with strong oxidants and strong bases, avoid mixing.
- Key Parameters: Purity ≥98.0% (HPLC); Moisture ≤0.5%; Melting Point Range 107-112°C; Heavy Metals ≤10 ppm; Residue on Ignition ≤0.1%.
Uses
2-(Trifluoromethyl)benzoic acid (CAS 433-97-6) is an important fluorinated aromatic carboxylic acid, widely used in pharmaceutical, agrochemical, organic synthesis and material chemistry fields due to its unique trifluoromethyl group and carboxylic acid functional group. In the pharmaceutical industry, it serves as a key intermediate for synthesizing antiviral, anti-inflammatory, central nervous system and anti-tumor drugs, and is also used in the synthesis of drug intermediates such as benzodiazepines and quinolones. In the agrochemical field, it is a core raw material for preparing high-efficiency fungicides (such as flutolanil), herbicides and insecticides, which can improve the biological activity and environmental stability of pesticides. In organic synthesis, it is used as a key reagent for introducing trifluoromethyl groups into complex molecules, and is widely applied in the synthesis of 1,3,4-oxadiazole derivatives, amides, esters and other compounds. In material chemistry, it is used as an intermediate for fluorinated liquid crystals, functional polymers and fluorinated coatings, helping to improve the thermal stability and hydrophobicity of materials. Additionally, it can be used as a research reagent in chemical analysis and laboratory research.
Packaging & Storage
Packaging: Laboratory grade: 10g, 50g, 100g sealed brown glass bottles (light-resistant and moisture-proof); industrial grade: 1kg, 5kg, 25kg aluminum foil bags or HDPE drums with inner PE liners, labeled with product name, CAS number, batch number, manufacturing date, expiry date, purity and storage precautions. Storage: Store in a cool, dry, dark and well-ventilated warehouse at room temperature (15-30°C); keep tightly sealed to prevent moisture absorption, agglomeration, light-induced decomposition and contamination; avoid humid environment, direct sunlight and strong oxidants; do not mix with toxic, harmful and incompatible substances. Shelf life: 24 months under recommended sealed, dry and dark storage conditions; use as soon as possible after opening to avoid performance degradation. Transportation: Avoid transportation under high temperature, strong light and rain; handle with care to prevent package damage and leakage; do not transport together with incompatible substances; no special low-temperature transportation is required, but avoid exposure to high temperature in summer. Handling: Operate in a well-ventilated area; avoid inhalation of powder and contact with skin, eyes and mucous membranes; wear dust-proof gloves, goggles and protective clothing during operation; wash skin thoroughly with soap and water after contact; if splashed into eyes, rinse with plenty of flowing water for 10-15 minutes and seek medical help in time; if swallowed, call a poison center or doctor immediately.
