Raloxifene hydrochloride
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
509.52
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder, odorless.
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise specializing in the research and development, manufacturing, and sales of fine chemicals. Headquartered in Jinan, Shandong, China, we are committed to delivering high-quality products to our global partners. Currently, over 90% of our products are exported to developed markets, including North America, Europe, Japan, South Korea, and the Middle East.
Physical Properties
- Appearance: White to off-white crystalline powder, odorless.
- Melting Point: 250–255 °C (slight decomposition at upper limit).
- Boiling Point: Decomposes before boiling under normal pressure, no definite boiling point.
- Solubility: Practically insoluble in water, soluble in methanol, slightly soluble in ethanol, insoluble in non-polar solvents like n-hexane.
- Density: Approximately 1.35 g/cm3 (calculated).
- Optical Activity: No optical activity (racemic mixture).
- Moisture Absorption: Slightly hygroscopic, easy to absorb moisture in air.
Chemical Properties
- Chemical Category: Non-steroidal selective estrogen receptor modulator (SERM), with benzothiophene, phenol, ketone and piperidine groups.
- Stability: Stable under ambient temperature and pressure; incompatible with strong oxidants and strong acids.
- Acid-Base Property: Weakly acidic (phenolic hydroxyl groups); aqueous solution of hydrochloride is weakly acidic (pH ≈ 5.0–6.0).
- Hydrolysis: Stable under neutral/weakly acidic conditions; slow hydrolysis under strong alkali (pH > 10).
- Photostability: Light-sensitive, easy to discolor and decompose under direct sunlight/ultraviolet light.
- Reactivity: Phenolic hydroxyl groups undergo esterification/alkylation; ketone group undergoes reduction; piperidine group undergoes quaternization.
Chemical Structure
Structural formula: $$\mathrm{C_{28}H_{27}NO_4S·HCl}$$
（Complete structural diagram can be provided separately on request）
Applications
- Selective estrogen receptor modulator (SERM) with estrogen-like effects on bone and anti-estrogen effects on breast/uterine tissues.
- Pharmaceutical API for prevention and treatment of postmenopausal osteoporosis.
- Biomedical research reagent for pharmacological experiments and hormone mechanism studies.
- Auxiliary raw material for pharmaceutical formulation development (tablets, capsules).
Storage & Handling
- Storage Condition: Sealed, dry, dark and well-ventilated warehouse; away from sunlight and heat sources.
- Recommended Temperature: 2–8 ℃ for long-term storage; 20–25 ℃ for short-term (≤7 days) sealed storage.
- Packaging: Aluminum foil bag vacuum packaging (10g/50g/100g) or chemical standard drum (1kg/5kg), moisture-proof and light-proof.
- Precautions: Avoid skin/eye contact; rinse with plenty of water if contacted. Store separately from corrosives, oxidants and food additives.
Description
Raloxifene Hydrochloride (CAS: 82640-04-8) is a non-steroidal selective estrogen receptor modulator. It is a white to off-white crystalline powder with high purity (≥99.0% HPLC), slightly hygroscopic and light-sensitive. It is widely used as pharmaceutical raw material, research reagent and formulation auxiliary. Store in strict accordance with requirements to ensure stability.
