p-Nitrobenzoyl-L-glutamic acid, with CAS No. 6758-40-3, is a high-purity organic fine chemical belonging to the glutamic acid derivative series, also known as N-(4-Nitrobenzoyl)-L-glutamic acid or (2S)-2-((4-Nitrobenzoyl)amino)pentanedioic acid. It is synthesized by the condensation reaction of p-nitrobenzoyl chloride and L-glutamic acid, with a single chiral center and specific optical activity. This product appears as a white to off-white crystalline solid, with uniform particle size, no visible impurities, and no obvious odor. It has stable physical and chemical properties, and is widely used in pharmaceutical R&D, biochemical experiments, and organic synthesis fields, serving as a key intermediate for vitamin M (folic acid) synthesis, a research tool for enzyme kinetics and protein structure studies, and a raw material for the synthesis of other fine chemicals, providing reliable support for pha
1. Physical Properties
p-Nitrobenzoyl-L-glutamic acid is a white to off-white crystalline solid, with uniform particle size, no visible impurities, and no obvious odor. It has a molecular weight of 296.23 Da, a melting point of 117-118°C, and a predicted density of 1.501 g/cm3 at 20°C; its predicted boiling point is 619.9±55.0°C at 760 mmHg, and the flash point is 328.7°C. It is very soluble in water, slightly soluble in ethanol and ethyl acetate, and insoluble in non-polar organic solvents such as chloroform and ether; it has a certain hygroscopicity, and long-term exposure to air or moisture may cause agglomeration, so it needs to be stored in a sealed and dry environment to maintain its stability.
2. Chemical Properties
Chemically, p-Nitrobenzoyl-L-glutamic acid is a glutamic acid derivative with a p-nitrobenzoyl group attached to the amino group of L-glutamic acid, containing a single chiral center (S-configuration) and specific optical activity. It contains carboxyl, amide and nitro functional groups in its molecular structure, and can undergo condensation, reduction, hydrolysis and other organic reactions; the nitro group in the molecule can be reduced to an amino group, which is an important reaction site for the synthesis of downstream products. It is stable under acidic, low-temperature and dark conditions, but is incompatible with strong oxidants; extreme acid-base environments or high temperatures will cause amide bond breakage and affect its chemical properties. Its acidity coefficient (pKa) is predicted to be 3.20±0.10, showing weak acidity in aqueous solution.
3. Storage & Safety Properties
Storage: It should be stored in a sealed, dry, and light-proof environment at -20°C, avoiding moisture, dust, high temperature, direct sunlight and strong oxidants. The packaging should be kept intact to prevent moisture absorption, contamination and agglomeration; it should not be mixed with toxic, harmful and corrosive substances. When taking, minimize the contact time with air, and seal the packaging immediately after use to avoid performance degradation. For short-term storage (within 1 week), it can be placed at 4°C, but repeated temperature changes should be avoided.
Safety: It is an irritant substance (GHS07, signal word: Warning), which may cause skin and eye irritation, and may cause respiratory discomfort if inhaled in the form of dust. It is not listed by ACGIH, IARC, or NTP as a carcinogen, and has no obvious acute toxicity. When handling, wear appropriate protective equipment (gloves, goggles, dust mask), and operate in a well-ventilated environment, minimizing dust generation and accumulation. In case of skin contact, wash thoroughly with plenty of water; in case of eye contact, rinse cautiously with water for several minutes (remove contact lenses if present and easy to do) and continue rinsing. If irritation persists, seek medical advice. This product is for industrial, pharmaceutical R&D and scientific research use only, not for direct human consumption without formulation. Disposal should be consistent with federal, state, and local regulations.
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