This is a specialty Fmoc-protected β-homo amino acid monomer exclusively for solid-phase peptide synthesis(SPPS) and medicinal chemistry research. Its side chain carries styryl conjugated alkenyl group, used to construct modified β-peptides, constrained cyclic peptides and peptidomimetic drug precursors targeting GPCR, protease inhibitor research. During peptide assembly, Fmoc protecting group can be removed by 20% piperidine/DMF under mild condition to expose free amino group for subsequent amino acid coupling reaction. Medicinal R&D labs introduce styryl unsaturated side chain into peptide skeleton to enhance molecule lipophilicity and cell membrane permeability for anti-cancer, anti-inflammatory peptide lead compound screening. Custom peptide synthesis factories adopt this raw material for labeled peptide, fluorescent modified peptide intermediate production. Strictly limited for lab research synthesis only, forbidden for food additive, feed additive and direct clinical pharmaceutical formulation preparation.
GHS irritant chemical with hazard statements H315(Skin Irritation), H319(Serious Eye Damage), H335(May cause respiratory irritation if inhaled dust). All weighing and feeding operations must be completed inside ventilated fume hood; operators need nitrile gloves, full-face splash goggles and dustproof lab coat to avoid powder inhalation and direct skin contact. In case of skin contact, wash contaminated area with plenty of soap and running water for more than 15 minutes; flush eyes continuously with abundant clean water over 15min once splashed, seek ophthalmic treatment for persistent redness and pain. Accidental oral intake will induce stomachache, nausea; large dosage ingestion requires prompt hospital symptomatic treatment. Waste solid residue and contaminated filter scraps belong to lab hazardous waste, deliver to qualified hazardous waste disposal institute complying with local environmental regulation, never pour residual waste into sewer. Separated storage with strong oxidants, concentrated inorganic acid to prevent decomposition and side reactions.
