Batch NO.:BBTT-0605-26 Assay(HPLC):99.41% Loss on Drying:0.12% Residue on Ignition:<0.06% Single Individual Impurity:≤0.07% Total Related Substances:≤0.25% Heavy Metal(Pb/Cd/As):＜10ppm Residual Organic Solvents:Meet ICH Q3C residual solvent limitation standard

This brominated biphenyl tetrazole derivative is core exclusive pharmaceutical intermediate for ARB antihypertensive APIs, not for food, feed or cosmetic raw material formulation. It serves as key starting material for Losartan, Valsartan, Irbesartan and Olmesartan Medoxomil bulk drug production, widely applied in commercial API synthesis factories and pharmaceutical R&D labs. The reactive benzyl bromide group enables nucleophilic substitution reaction with imidazole/imidazoline side chain fragments to construct finished drug molecular skeleton; trityl group acts as protective group for tetrazole ring to prevent side reactions during multi-step synthesis, removable under acidic deprotection condition at later synthetic stage. High-purity grade is supplied as impurity reference standard for valsartan/irbesartan finished drug quality inspection and HPLC method validation in pharmaceutical QC labs. Small lab batches are used for novel angiotensin antagonist drug candidate synthesis and medicinal chemistry custom research, no agrochemical or daily chemical formulation application available.

GHS Category 6.1 toxic irritant with hazard statements H302(harmful if swallowed), H315(skin corrosion/irritation), H319(serious eye damage), H335(respiratory tract irritation from dust inhalation). All weighing and feeding operations must run inside fume hood; operators equip nitrile resistant gloves, full-face splash goggles and dustproof lab overall to block bromomethyl dust contact and inhalation. Upon skin exposure, flush contaminated skin with abundant running soapy water for minimum 15 minutes; for eye splashing, continuous eye irrigation with purified water over 15 min and immediate ophthalmic consultation if irritation persists. Accidental oral intake causes stomachache, vomiting and digestive discomfort; massive ingestion needs urgent hospital symptomatic treatment. Waste solid residues and spent solvent waste belong to hazardous pharmaceutical waste, hand over to licensed professional waste disposal institution following local environmental regulation, prohibited from direct sewer discharge or domestic waste discard. Keep separate storage with strong base, strong oxidizer and nucleophilic amine chemicals to prevent violent substitution and exothermic decomposition reaction.