Shandong Huashang Chemical Co., Ltd.
Product
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
  • Brand:HuaShang
  • Model:25kg/drum
  • Purity:99%
  • Cas:125700-67-6
  • Createtime: 2026-04-14
  • Updatetime: 2026-04-15
Product Details
useage Industrial use
deliveryInfo
appearance powder
Storage Sealed tight, stored at 2~8℃, cool dry dark warehouse, isolate from moisture, strong acid & strong alkali
aliasen
supplyCapacity 50000Metric Ton/Month
Solubility Soluble in acetonitrile(100mg/mL), DMF(160mg/mL); slightly soluble in water(3mg/mL@20℃); insoluble in alkanes, ether
harbor Qingdao,China
minorder 1KG
Melting Point 205℃
Batch NO.:TBTU260604
Assay(HPLC):99.32%
Loss on Drying:0.21%
Residue on Ignition:0.05%
Heavy Metal(Pb):<10ppm
Arsenic:<2ppm
Total Related Impurity:≤0.30%
Residual Solvent: Complies with ICH Q3C limitation


Product Usage

TBTU is a mainstream uronium-type peptide coupling reagent, exclusively used for laboratory fine chemical synthesis & pharmaceutical intermediate preparation, prohibited for food, cosmetic or direct human medication raw material.
  1. Core application in solid-phase & liquid-phase peptide synthesis: Activate carboxylic acid group to form amide linkage, effectively suppress amino acid racemization during condensation, ideal for sterically hindered amino acid coupling; often used together with HOBt to raise coupling yield for peptide API intermediates.
  2. Organic synthetic building block: Catalyze synthesis of 1,2,4-oxadiazole heterocyclic compounds from carboxylic acid raw materials; selective deprotection for THP ether, DMT protecting group in nucleoside & oligonucleotide synthesis.
  3. High-purity grade serves as analytical reference standard for HPLC qualitative verification of similar uronium coupling reagents in lab quality inspection.

Safety Information

GHS Hazard Level: Warning; Hazard Statements: H315(Skin Irritation), H319(Serious Eye Damage), H335(May cause respiratory irritation).
Full PPE required during operation: nitrile gloves, dust-proof goggles, dustproof lab coat to avoid dust inhalation, skin & eye contact.
Waste solid & waste solvent containing TBTU are classified as lab hazardous waste, delivered to qualified certified disposal institute per local environmental laws, forbid random domestic waste discard.
Acute oral ingestion triggers gastrointestinal discomfort(nausea, stomach ache); long-term repeated inhalation may induce allergic respiratory inflammation, complete carcinogenic & reproductive toxicity data uncompleted currently.
Emergency treatment: Rinse contaminated skin/eyes with abundant running water over 15min; seek medical help for persistent irritation.
Separate storage from strong oxidants, strong base to prevent hydrolysis decomposition and purity decline.