Phenethylammonium citrate is a chiral organic ammonium salt formed by phenethylamine and citric acid, widely used as chiral resolving agent and pharmaceutical fine chemical intermediate in asymmetric organic synthesis. Its inherent chiral ammonium cation structure is core for optical resolution of carboxylic acid, amine and amino acid racemates via salt-forming crystallization separation, commonly adopted in chiral API splitting for cardiovascular and central nervous system drugs. In pharmaceutical R&D field, it serves as starting material to prepare phenethylamine-derived antibacterial and antifungal small-molecule candidates due to inherent mild bacteriostatic activity against gram-positive bacteria and partial fungi. Besides synthetic chemistry, high purity grade is applied as analytical standard for HPLC calibration of phenethylamine residues in food and pharmaceutical raw materials. It is also used as additive in cosmetic preservative compound formulation and laboratory biochemical reagent for enzyme activity screening research. Bulk fine chemical factories stock this product for custom chiral resolution outsourcing service globally.
Low acute oral toxicity to human and mammals. Direct skin contact induces erythema and itching; rinse polluted skin with abundant running tap water for over 15 min immediately after exposure. Crystal dust splashed into eyes leads to stinging and conjunctival hyperemia, keep continuous eye washing no less than 15 minutes and visit doctor if irritation persists. Inhalation of fine powder irritates nasopharynx and trachea to trigger cough and throat discomfort; all weighing and feeding operations must be done in ventilated fume hood with nitrile gloves, dust-proof goggles and disposable respirator. Store separately from foodstuff, strong oxidizers and corrosive reagents in cool dry shaded warehouse; production waste liquid and solid residues shall be disposed as general chemical waste complying with local environmental rules, prohibited from direct drainage into water and soil.
