This fluorinated triazole ketone is core pharmaceutical intermediate and EP reference impurity standard of Fluconazole (Fluconazole EP Impurity E). Primarily applied for manufacturing azole antifungal APIs including fluconazole and voriconazole via nucleophilic addition and chiral reduction reaction to construct triazole side chain skeleton of antifungal medicine. In pharmaceutical quality control industry, high-purity grade serves as certified impurity reference substance for fluconazole raw material and finished dosage formulation detection, used for HPLC qualitative & quantitative analysis during API production compliance inspection per European Pharmacopoeia standard. Besides antifungal drug synthesis, it is also building block for novel triazole-containing agrochemical bactericides and plant antifungal agents targeting crop pathogenic fungi like candida and aspergillus. Advanced lab research employs this compound for developing new COX inhibitor and anti-infective small-molecule drug candidates via derivatization of ketone active group, widely stocked by pharmaceutical R&D labs and impurity standard manufacturers globally.
Low acute oral toxicity, but irritating to skin, ocular mucosa and respiratory tract. Direct skin contact causes redness and itchiness; flush contaminated skin with running clean water over 15 minutes once exposed. Dust splashing into eyes triggers stabbing pain and conjunctival congestion, keep continuous eye rinsing for minimum 15 min and seek medical treatment if persistent irritation occurs. Inhalation of fine powder irritates nasal and throat mucosa leading to cough and throat discomfort, all feeding and sampling operations must be conducted in ventilated fume hood equipped with nitrile gloves, anti-dust goggles and half-face dust respirator. Store separately from food, strong oxidants and corrosive chemicals in shaded low-temperature warehouse; waste residues and mother liquor must be treated as pharmaceutical hazardous waste following local environmental regulations, forbidden arbitrary discharge into water system and soil.
