Puerarin is a natural isoflavone C-glucoside isolated from Pueraria lobata (kudzu root), widely used in pharmaceutical, nutraceutical, and cosmetic fields. As a key active ingredient, it exhibits vasodilation, anti-inflammatory, antioxidant, and neuroprotective effects. It is clinically used for treating coronary heart disease, angina, hypertension, and sudden deafness by improving microcirculation and increasing coronary blood flow. In research, it acts as a 5-HT2C receptor and benzodiazepine site antagonist, serving as a tool compound for neuroscience studies. In cosmetics, it functions as an antioxidant to scavenge free radicals and protect skin from aging.

GHS Classification: H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation) Signal Word: Warning Risk Codes: R11; R36/37/38 Safety Codes: S16; S22; S24/25; S26; S36/37/39; S45

Acute toxicity: Rat oral LD50 >5 g/kg (low acute toxicity). Skin contact may cause redness, itching, and dermatitis; rinse with plenty of water. Eye contact can lead to severe irritation; flush with clean water for ≥15 minutes and seek medical attention. Inhalation of dust may irritate the respiratory tract. Use in a well-ventilated area; wear nitrile gloves, safety goggles, and a dust mask during handling. Store separately from food, feed, and oxidants. Dispose of waste per local hazardous waste regulations.