6-Methyl-9,10-didehydroergoline-8-carboxylic acid is an indispensable core intermediate of ergot alkaloid series. In pharmaceutical manufacturing, it serves as critical starting material to synthesize ergotamine, bromocriptine and cabergoline, which are clinically applied for migraine relief, Parkinson’s disease treatment and hyperprolactinemia control. Its unique indole-fused quinoline skeleton enables selective binding with dopamine and serotonin receptors, supporting the development of novel central nervous system related therapeutic agents. For academic research, it works as a standard tool compound targeting 5-HT receptors to explore neuroregulatory mechanism, psychopharmacology and drug addiction pathways. Restricted by global chemical control regulations as a controlled precursor substance, this chemical can only be purchased, processed and used by qualified licensed pharmaceutical factories and certified research institutions. It is forbidden for unauthorized trading or casual laboratory usage, with strict whole-process supervision covering production, transportation and inventory management in related industries.
GHS Classification: H300 (Fatal if swallowed), H310 (Fatal in contact with skin), H330 (Fatal if inhaled), H341 (Suspected of causing genetic defects), H361 (Suspected of damaging fertility or the unborn child), H370 (Causes damage to organs), H410 (Very toxic to aquatic life with long lasting effects). Signal Word: Danger, UN Number: UN2811. Acute oral LD50 of rat is lower than 5 mg/kg, featuring extreme toxicity via oral, dermal and inhalation routes. Direct skin or eye exposure triggers severe corrosion and irreversible tissue injury; inhaled dust induces respiratory failure and systematic neurotoxicity. Accidental ingestion leads to hallucination, convulsion and multiple organ failure. Long-term repeated exposure damages liver, kidney and nervous system with potential teratogenic and carcinogenic risks. All operations must be conducted in certified fume hoods with full chemical protective suit, splash goggles and respirator. Store under dual-lock management in cool dark warehouse away from oxidants and strong acids. Contaminated residues need professional hazardous waste disposal complying with local regulatory codes.
