Shandong Huashang Chemical Co., Ltd.
Product
Benzeneacetamide, 3-chloro-N-(1-methyl-1-phenylethyl)-
  • Brand:HuaShang
  • Model:25kg/drum
  • Purity:99%
  • Cas:76440-30-7
  • Createtime: 2026-04-14
  • Updatetime: 2026-04-15
Product Details
Boiling Point 425.3 ± 35.0 °C
useage Industrial use
deliveryInfo
appearance powder
Storage Sealed, cool dry place (2–8 °C recommended), away from strong oxidants and direct sunlight
aliasen
supplyCapacity 50000Metric Ton/Month
Solubility Insoluble in water; soluble in methanol, ethanol, DMSO, and dichloromethane
harbor Qingdao,China
minorder 1KG
Melting Point 108–110 °C
  1. Appearance: White crystalline powder
  2. Purity (HPLC): ≥98.0% (typically ≥98.5%)
  3. Moisture: ≤0.3%
  4. Melting Point: 108–110 °C
  5. Total Impurities: ≤1.0%


Application

This compound is a custom pharmaceutical intermediate featuring a diaryl-substituted acetamide scaffold. It is primarily used in the synthesis of central nervous system (CNS) modulators, especially as a key precursor for developing selective serotonin reuptake inhibitors (SSRIs) and norepinephrine-dopamine reuptake inhibitors (NDRIs). Its unique 3-chlorophenyl and 2-phenylisopropyl substituents enable high binding affinity to neurotransmitter receptors, making it valuable for research into antidepressants, anxiolytics, and cognitive enhancers. It also serves as a building block in organic synthesis for constructing complex nitrogen-containing heterocyclic molecules in drug discovery programs.

Safety Information

GHS Classification: Warning (predicted)
Hazard Statements: H315 (Causes skin irritation); H319 (Causes serious eye irritation); H335 (May cause respiratory irritation)
  • Acute toxicity: Oral LD50 (rat) >2000 mg/kg (slightly toxic, predicted)
  • Skin/eye irritation: Moderate irritant; direct contact may cause redness, itching, or conjunctival inflammation
  • Inhalation: Dust or powder may irritate the respiratory tract, causing cough or throat discomfort
  • Handling: Use in a fume hood; wear nitrile gloves, safety goggles, and a dust mask
  • Storage: Keep away from strong acids, oxidants, and food; store in a cool, dry, well-ventilated area
  • First aid: Rinse skin with plenty of soapy water; flush eyes with running water for 15 minutes; seek medical attention if swallowed or inhaled