Shandong Huashang Chemical Co., Ltd.
Product
2-HYDROXY-4-TRIFLUOROMETHYL-BENZOIC ACID METHYL ESTER
  • Brand:HuaShang
  • Model:25kg/drum
  • Purity:99%
  • Cas:345-28-8
  • Createtime: 2026-04-14
  • Updatetime: 2026-04-15
Product Details
Boiling Point 245 °C
useage Industrial use
deliveryInfo
appearance powder
Storage Sealed, dry, room temperature
aliasen
supplyCapacity 50000Metric Ton/Month
harbor Qingdao,China
minorder 1KG
  1. Appearance: Colorless to pale yellow clear liquid
  2. Purity (GC): ≥97.0%
  3. Moisture: ≤0.2%
  4. Density (25 °C): 1.380–1.385 g/cm3
  5. Boiling Range: 243–247 °C
  6. Refractive Index: 1.460–1.465 (20 °C)


Application

Methyl 2-hydroxy-4-(trifluoromethyl)benzoate is a key fluorinated aromatic intermediate widely used in pharmaceutical, agrochemical, and fine chemical synthesis. Its unique structure with a trifluoromethyl group and hydroxyl-ester functional groups enables high chemical stability and selective reactivity, making it a critical building block for introducing fluorine atoms into complex molecules. In pharmaceuticals, it is primarily utilized for synthesizing anti-inflammatory, analgesic, and antiviral drug candidates, as well as intermediates for central nervous system (CNS) agents. In agrochemicals, it serves as a precursor for high-efficiency herbicides, fungicides, and insecticides with enhanced bioavailability and environmental compatibility. Additionally, it is applied in the production of functional dyes, liquid crystal materials, and polymer additives, leveraging the trifluoromethyl group’s ability to improve thermal stability and chemical resistance. Its broad applicability and high purity make it an essential raw material for advanced chemical synthesis.

Safety Information

GHS07 (Warning): Skin irritant; eye irritant; may cause respiratory irritation.
  • Routes of Entry: Inhalation, ingestion, skin/eye contact
  • Acute Toxicity: Oral LD50 (rat) >2,000 mg/kg (Category 5); low dermal toxicity
  • Skin Contact: Causes mild to moderate irritation, redness, itching; prolonged contact may cause dryness
  • Eye Contact: Irritating; may cause redness, tearing, temporary discomfort; rinse with plenty of water for 15 minutes and seek medical attention
  • Inhalation: Vapor may irritate respiratory tract, causing cough or sore throat; use in well-ventilated areas with masks
  • Ingestion: May cause nausea, vomiting, abdominal discomfort; do not induce vomiting, rinse mouth and seek medical advice
  • Precautions: Wear protective gloves, safety goggles, and lab coat; avoid breathing vapor
  • Storage: Keep tightly closed in a cool, dry place; separate from oxidants
  • Transport: Not classified as dangerous goods; UN 3082, Class 9, Packing Group III