This chiral amino-alcohol with trans-stereochemistry is a key heterocyclic building block, widely used in pharmaceutical and bioconjugation chemistry. The cis-aminohydroxy structure on the tetrahydrofuran ring provides distinct stereochemical control, enabling precise molecular modification. It serves as a critical linker in antibody-drug conjugates (ADCs), improving the water solubility and stability of conjugated payloads. In drug synthesis, it is used to prepare antitumor, antiviral and central nervous system agents via nucleophilic substitution and condensation reactions. Its unique cyclic structure helps enhance metabolic stability and target binding affinity of drug molecules. Additionally, it is applied in the synthesis of chiral intermediates, biochemical reagents and fine chemicals, playing an important role in modern drug development and organic synthesis.

This compound is classified as a low-toxicity irritant (GHS07, Warning). It may cause allergic skin reactions (H317) and is harmful if swallowed (H302). Inhalation of dust may irritate the respiratory tract, causing cough or discomfort. Wear protective gloves, goggles and dust mask during handling. Avoid direct skin contact; in case of contact, rinse with plenty of water. If eye contact occurs, flush eyes with water for 15 minutes and seek medical attention. Store away from strong oxidants and acids. Thermal decomposition may produce toxic nitrogen oxides. Dispose of waste in accordance with local regulations to prevent environmental pollution.