1. Appearance: Off-white solid powder
2. Purity (HPLC): ≥98.0%
3. Melting Point: Not available
4. Moisture: ≤0.5%
5. Residue on Ignition: ≤0.1%
6. Heavy Metals: ≤10 ppm
7. Related Substances: ≤1.0%

Applications

• Biochemical Research: Potent ATP-competitive inhibitor of Src, Abl, and Kit kinases.
• Anticancer Research: Exhibits antiproliferative activity against CML (chronic myeloid leukemia) cell lines and Bcr-Abl-transformed cells (IC?? = 14 nM).
• Mechanism Study: Blocks Bcr-Abl tyrosine phosphorylation, induces G0/G1 cell cycle arrest, and promotes apoptosis in Kit-mutated tumor cells.
• Drug Development: Tool compound for researching kinase signaling pathways and developing targeted anticancer drugs.

Safety Information

• Handling: Wear nitrile gloves, safety goggles, and dust mask; operate in a fume hood.
• Storage: Store at -20°C, sealed, under inert gas (nitrogen/argon), away from light and moisture.
• Disposal: Dispose of as hazardous waste in accordance with local regulations.