Hemokinin 1 (human) acetate is an endogenous peptide and selective agonist of the tachykinin NK1 receptor, with high affinity (IC?? = 1.8 nM for NK1; 370 nM for NK3; 480 nM for NK2). It serves as a critical research tool in neuropharmacology, immunology, and cardiovascular studies. In neuroscience, it is widely used to investigate NK1 receptor signaling, pain modulation, and neurogenic inflammation, as it mimics substance P actions in the central and peripheral nervous systems. In immunology, it exhibits proliferative and antiapoptotic effects on B-cells in vitro, supporting studies on lymphocyte function and immune regulation. In cardiovascular research, it demonstrates antihypertensive activity in vivo, making it a valuable probe for studying blood pressure regulation and vasodilation mechanisms. Additionally, it is employed in drug discovery programs targeting NK1 receptors for pain, depression, and inflammatory disorders, as well as in developing novel peptide-based therapeutics. Its high purity and biological stability enable reliable in vitro and in vivo research applications.

This peptide is classified as low-to-moderate hazard under standard laboratory handling conditions. Skin contact may cause mild irritation, redness, or itching due to potential pro-inflammatory effects via local NK1 receptor activation; prolonged or repeated exposure may increase sensitivity, so chemical-resistant gloves should be worn, and contaminated skin rinsed with water. Eye contact may induce transient stinging, tearing, or conjunctival redness; protective goggles are required, and eyes should be flushed with water for 15 minutes if contact occurs. Inhalation of dust or lyophilized powder may irritate the respiratory tract, causing cough or throat discomfort; work in a fume hood and wear a dust mask to avoid aerosol formation. Ingestion of small amounts may cause mild gastrointestinal upset (nausea, abdominal discomfort); large doses may trigger more severe symptoms, so oral exposure must be prevented. It is non-flammable and chemically stable at room temperature but decomposes at high temperatures, releasing irritating fumes. Store sealed at -20 °C, separate from oxidants and food. Dispose of waste per local regulations to avoid environmental contamination.