Alprenolol (CAS 13655-52-2) is a non-selective β-adrenergic receptor antagonist with additional 5-HT receptor blocking activity, widely used in pharmaceutical research and clinical medicine. As a beta-blocker, it competitively inhibits β-receptors in the heart, blood vessels, and bronchi, reducing heart rate, blood pressure, and myocardial oxygen consumption. Clinically, it is indicated for hypertension, angina pectoris, arrhythmias, and anxiety-related tachycardia. It also serves as a research tool in pharmacology to study β-receptor function and signaling pathways. In drug development, it is used as a reference compound for screening novel β-blockers and studying receptor-ligand interactions. Its high purity and well-characterized pharmacological profile make it essential for in vitro and in vivo studies, supporting the discovery of new cardiovascular and neuropsychiatric drugs.

Alprenolol is classified as a toxic substance (GHS: H301, H311, H331, H317). Inhalation of dust or powder may cause respiratory irritation, dizziness, or shortness of breath; work in a fume hood and wear a respirator. Skin contact can lead to toxicity through absorption, causing redness, itching, or allergic reactions; wear chemical-resistant gloves and wash skin thoroughly after handling. Eye contact may result in severe irritation, pain, or conjunctivitis; flush eyes with water for 15 minutes and seek medical attention. Ingestion is highly toxic, causing nausea, vomiting, bradycardia, hypotension, or even cardiac arrest; do not induce vomiting and seek emergency treatment. Store in a cool, dry, secure place, away from incompatible substances. Dispose of waste in accordance with hazardous waste regulations to prevent environmental contamination.