- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
2-Amino-5-chloro-3-methylpyridine is a trisubstituted pyridine heterocyclic intermediate with amino, chloro and methyl groups. It has good chemical reactivity, suitable for nucleophilic substitution, Suzuki coupling, Buchwald amination and derivatization reactions. Widely used as core building block for antitumor, anti-inflammatory, central nervous system pharmaceutical intermediates, kinase inhibitor fragments and targeted small molecule drugs; also used in medicinal chemistry SAR research, custom fine chemical synthesis and pesticide intermediate development.
Safety Information
Irritating to skin, eyes and respiratory tract. Avoid dust inhalation, prolonged skin contact and direct eye exposure. Operate in a fume hood with nitrile gloves, safety goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed in dry, dark and ventilated environment. Waste shall be disposed in accordance with hazardous chemical regulations.
