- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
2-Amino-5-chloropyridine is a common disubstituted pyridine heterocyclic intermediate with amino and chloro groups on the pyridine ring. It has high chemical reactivity and can participate in diazotization, nucleophilic substitution, Suzuki coupling, Buchwald amination and condensation reactions. It is widely used as key building block for antitumor, anti-inflammatory, antibacterial and central nervous system drug intermediates, kinase inhibitor fragments and targeted small molecule drug synthesis. It is also applied in medicinal chemistry structure-activity relationship research, custom fine chemical synthesis and new agrochemical fungicide and herbicide intermediate development.
Safety Information
Irritating to skin, eyes and respiratory tract. Inhalation of dust may cause throat discomfort, dry cough and respiratory mucosal irritation; direct eye contact leads to stinging, redness and conjunctival congestion. Prolonged skin contact may cause dryness and allergic irritation. Avoid dust inhalation, prolonged skin contact and eye exposure. All operations should be carried out in a fume hood with nitrile gloves, safety goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed in dry, dark and ventilated environment. Waste residues and packaging materials shall be disposed strictly in accordance with hazardous chemical regulations to avoid water and soil pollution.
