- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
4-Chloro-7-methylquinazoline is a key methyl-substituted quinazoline heterocyclic intermediate. The 4-position chlorine has high chemical activity, easily participating in nucleophilic substitution, amination and coupling reactions. It is widely used as core building block for tyrosine kinase inhibitors, antitumor targeted drugs, anti-inflammatory and central nervous system pharmaceutical intermediates. It is also applied in medicinal chemistry structure-activity relationship research, custom organic synthesis and development of new agrochemical fungicides and fine chemical derivatives.
Safety Information
Irritating to skin, eyes and respiratory tract. Inhalation of dust may cause throat discomfort and dry cough; direct eye contact leads to stinging, redness and conjunctival congestion. Avoid dust inhalation and prolonged skin contact. All operations should be performed in a fume hood with nitrile gloves, safety goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed away from light and moisture. Waste shall be disposed in strict accordance with hazardous chemical regulations to avoid environmental pollution.
