- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Melting Point: 78–82 °C
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
2-Amino-5-chloropyridine is a crucial halogenated pyridine heterocyclic intermediate with amino and chloro groups on the pyridine ring. It readily undergoes diazotization, nucleophilic substitution, condensation and Suzuki/Buchwald cross-coupling reactions, widely used to construct multi-substituted pyridine derivatives and fused heterocyclic molecular skeletons in organic synthesis.
In pharmaceutical industry, it serves as core building block for antitumor, anti-inflammatory, antibacterial, nervous system and cardiovascular drug intermediates, also applied in synthesis of kinase inhibitors and small-molecule targeted drugs. In agrochemicals, it is used for high-efficiency fungicides, herbicides and insecticide intermediates. It is also widely used in organic optoelectronic materials, liquid crystal intermediates, dye synthesis and laboratory customized fine chemical research.
Safety Information
Irritating to skin, eyes and respiratory tract. Direct skin contact may cause redness, itching and mild inflammation; long-term exposure may induce skin sensitization. Eye contact leads to stinging, conjunctival congestion and tearing, rinse immediately with plenty of running water. Inhalation of dust irritates throat and bronchial mucosa, causing dry cough and respiratory discomfort. Accidental ingestion may cause mild nausea and gastrointestinal upset.
Harmful to aquatic organisms, prohibited from direct discharge into water and soil. Operate in ventilated fume hood, wear nitrile gloves, chemical goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed, dry and away from light. Waste and packaging disposed per hazardous chemical waste regulations.
