- Assay (HPLC): ≥98.0%
- Appearance: White to off-white crystalline powder
- Melting Point: 76–80 °C
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- Single Impurity: ≤0.2%
- Total Impurity: ≤1.0%
Applications
2-Amino-5-bromopyridine is a key brominated pyridine heterocyclic intermediate, containing amino and bromo substituents on pyridine ring. It can undergo diazotization, substitution, condensation and Suzuki cross-coupling reactions, widely used to construct multi-substituted pyridine derivatives and fused heterocyclic skeletons in organic synthesis.
In pharmaceutical industry, it is an important raw material for antitumor, anti-inflammatory, antibacterial and neurological drug intermediates, also used in synthesis of kinase inhibitors and small molecule targeted drugs. In agrochemicals, it is applied to prepare high-efficiency fungicides, herbicides and insecticide intermediates. It is also commonly used in organic optoelectronic materials, liquid crystal intermediates, dye synthesis and laboratory custom fine chemical research.
Safety Information
Irritating to skin, eyes and respiratory tract. Direct skin contact may cause redness, itching and mild inflammation; long-term exposure may induce skin sensitization. Eye contact will cause stinging, conjunctival congestion and tearing, need immediate rinsing with plenty of running water. Inhalation of dust irritates nasal and bronchial mucosa, causing throat dryness, cough and chest discomfort. Accidental ingestion may trigger mild gastrointestinal nausea and abdominal distension.
Harmful to aquatic organisms, prohibited from direct discharge into water and soil. Operate in ventilated fume hood, wear nitrile gloves, chemical goggles and dust mask. Keep away from high temperature, open flame and strong oxidants. Store sealed, dry and away from light. Waste and packaging disposed in accordance with hazardous chemical waste regulations.
