2-Bromo-5-chloropyridine is an important dihalogenated pyridine heterocyclic building block. It contains both bromine and chlorine reactive sites on the pyridine ring for selective coupling reaction. It can be used for Suzuki, Heck, Sonogashira and Buchwald-Hartwig cross-coupling reactions. Widely applied as key intermediate in synthesis of kinase inhibitors, anticancer drugs, anti-inflammatory and CNS medicinal compounds. Also used for medicinal chemistry compound library construction and structure-activity relationship research.